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ORIGINAL ARTICLE
Year : 2010  |  Volume : 13  |  Issue : 1  |  Page : 55-57

Determination of antibacterial activity of Carica papaya (paw­-paw) extracts


1 Department of Medical Microbiology/Parasitology, College of Health Sciences, Nnamdi Azikiwe University Nnewi Campus, Nigeria
2 Department of Medical Microbiology/Parasitology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria

Correspondence Address:
C N Akujobi
Department of Medical Microbiology/Parasitology, College of Health Sciences, Nnamdi Azikiwe University Nnewi Campus
Nigeria
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Objective: The quest for suitable and affordable alternatives in the face of increasing antimicrobial drug resistance has led researchers into exploring the use of plant extracts in the treatment of infections. Method: Antibacterial activity of extracts of carica papaya (paw-paw) fruit was investigated using isolates from wound culture. These include: Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and proteus species. These organisms were challenged with extracts from the seed, endocarp and epicarp. Result: The extracts demonstrated antibacterial activity as shown by their zones of inhibition and this was more pronounced with alcohol extracts than that of water. Staphylococcus aureus was the most susceptible with a minimum inhibition concentration (MIC) of 1:64 while Enterococcus faecalis was the least sensitive. The extracts were also heat stable. Conclusion: The demonstration of antibacterial activity against both gram positive and gram negative bacteria demonstrates that the paw-paw plant is a potential source for the production of antimicrobial drugs. Researchers should be encouraged towards utilizing this plant as well as others with such potential in other to curb the menace of antimicrobial drug resistance in the near future.


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