Medical and Dental Consultantsí Association of Nigeria
Home - About us - Editorial board - Search - Ahead of print - Current issue - Archives - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 1129   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Year : 2012  |  Volume : 15  |  Issue : 1  |  Page : 55-58

Antioxidant status of type 2 diabetic patients in Port Harcourt, Nigeria

Department of Chemical Pathology, University of Port Harcourt Teaching Hospital, PMB, Port Harcourt, Rivers State, Nigeria

Correspondence Address:
E P Odum
Department of Chemical Pathology, UPTH, Port Harcourt
Login to access the Email id

Source of Support: Chemical Pathology Research Laboratory, UPTH, Port Harcourt, Conflict of Interest: None

DOI: 10.4103/1119-3077.94099

Rights and Permissions

Context: Oxidative stress has been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and its complications. Aims: This study was conducted to determine and compare total antioxidant status (TAS), vitamin C and E levels in T2DM patients and healthy control subjects. Settings and Design: Fifty-five previously diagnosed DM patients aged between 34 years and 70 years and 50 control subjects aged between 35 years and 69 years were consecutively recruited into this study. Materials and Methods: Blood pressure (mmHg), body mass index (kg/m 2 ), concentrations of plasma glucose (mmol/l), lipid profile (mmol/l), TAS (mmol/l), vitamins C (μmol/l), and E (μmol/l) were determined in all participants. Statistical Analysis Used: Statistical Package for Social Sciences (SPSS) version 11.0 was used for statistical analysis. Results: The mean plasma TAS (1.18 ± 0.27 mmol/l), vitamin C (26.59 ± 7.39 μmol/L) and vitamin E (15.33 ± 4.05 μmol/l) of T2DM patients were significantly lower (P=0.0001 for all) than those of controls (1.58 ± 0.28 mmol/l, 43.56 ± 6.86 μmol/l, 31.22 ± 6.20 μmol/l respectively). TAS had a positive correlation with vitamin E (r=0.588; P=0.013) but no correlation with vitamin C (r=−0.387; P=0.139) among diabetics. Conclusions: TAS, vitamin C and E levels are reduced in T2DM patients compared with those of controls.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded538    
    Comments [Add]    
    Cited by others 10    

Recommend this journal