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ORIGINAL ARTICLE
Year : 2015  |  Volume : 18  |  Issue : 2  |  Page : 178-182

Sonographic analysis of adult polycystic kidney disease: Retrospective data from South-East Nigeria


1 Department of Radiation Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
2 Department of Radiology, Ahmadu Bello University, Zaria, Nigeria

Date of Acceptance24-Mar-2014
Date of Web Publication10-Feb-2015

Correspondence Address:
N I Iloanusi
Department of Radiation Medicine, University of Nigeria Teaching Hospital, Enugu
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1119-3077.151037

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   Abstract 

Background: Autosomal dominant polycystic kidney disease (APKD), an inheritable multisystem disease characterized by intrarenal and at times extrarenal disease, has been studied extensively among Caucasian populations. Despite the fact that being black is a risk factor for progressive disease, there is paucity of local published data. As a result, true local incidence and peculiarities in clinical and sonographic characteristics are unknown.
Aim: To present data from 19 patients diagnosed with APKD in a medium-sized facility over a 16-year period.
Materials and Methods: A retrospective search was done on the ultrasound registers for patients who had undergone abdominal ultrasound in 16 years (1997-2013). Of the 29 sonographic diagnoses of bilateral PKD made, only 19 had complete records and were included in the study. Data extracted were- age, sex, working diagnosis, renal size, diameter of renal cysts, presence or absence of extrarenal cysts, family history of renal cystic disease, blood pressure at diagnosis, and patient outcome.
Results: A total of 19 diagnoses of APKD were made- 12 males and seven females with a sex ratio of 1:0.6. Total mean age was 54.8 years (range 31-79 years)- 40.1 years for females and 57.2 years for males. In 89.5% of cases, no family history of APKD was obtained. Only six (31.6%) patients were hypertensive at presentation and three patients (16%) were already in renal failure. Ultrasound showed a mean renal size of 88.92 cm 2 for the right kidney and 98.97cm 2 for the left. Mean cyst diameter was 3.46 cm (range 2.08-4.85cm). Only one patient had documented extrarenal cystic disease. Two patients were lost to renal failure and congestive cardiac failure.
Conclusion: APKD appears to be uncommon in our environment; however, more studies may be elucidatory. Standard sonographic protocol for collecting data from patients with APKD is needed.

Keywords: Polycystic kidneys, screening, ultrasound


How to cite this article:
Okere P, Ezeofor S N, Iloanusi N I, Ibinaiye P O, Okoye I J. Sonographic analysis of adult polycystic kidney disease: Retrospective data from South-East Nigeria. Niger J Clin Pract 2015;18:178-82

How to cite this URL:
Okere P, Ezeofor S N, Iloanusi N I, Ibinaiye P O, Okoye I J. Sonographic analysis of adult polycystic kidney disease: Retrospective data from South-East Nigeria. Niger J Clin Pract [serial online] 2015 [cited 2019 Sep 18];18:178-82. Available from: http://www.njcponline.com/text.asp?2015/18/2/178/151037


   Introduction Top


Autosomal dominant polycystic kidney disease (APKD) is a multisystem hereditary [1] disease typified by renal parenchymal cysts and extrarenal cystic and non-cystic changes (See [Figure 1]a and b). It is a monogenic disorder and has been sonologically diagnosed in utero[2] and literature from Caucasian population studies suggests that it is a common condition. [3] While available local literature asserts that APKD is rare in blacks, [4],[5],[6] being a black male has been a recognized risk factor for progressive disease. [7],[8],[9] However, data [10],[11] that may contribute to the determination of its local prevalence along with possible peculiarities in its clinical and sonographic features remain sparse. Yet, the incidence of renal impairing disease worldwide (Nigeria inclusive) is high. [12],[13],[14],[15],[16] In addition, APKD, a progressive renal disease with a relatively long course [2],[17],[18] is indicted as the fourth leading cause of end stage renal disease in adults. [17],[19] In the course of this disease, there is morbidity from destruction of renal parenchyma in more than half of affected patients. [18],[20],[21],[22],[23] In addition there are other extrarenal non-cystic manifestations such as intracranial vascular aneurysms whose rupture may lead to death or disability. [24] Hypertension is a frequent finding in patients with APKD. [25],[26] Renal ultrasound has been used in the detection of cysts APKD. [27],[28] These cysts appearing as thin-walled structures containing echo-clear fluid with distinct posterior enhancement [29] progressively increase in size at variable rates. [30],[31] Renal insufficiency ultimately supervenes. [30],[31],[32],[33]
Figure 1 : (a) Transverse ultrasound scan of the left kidney showing multiple parenchymal cysts. (b) Longitudinal ultrasound scan of the left kidney showing multiple parenchymal cysts

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   Materials and Methods Top


A detailed search of ultrasound registers of patients who had undergone abdominal scans for various indications in the past 16 years at the ultrasound clinic of a specialist hospital in south-east Nigeria was done. Of the 33,280 patients referred for abdominal scans within the period, 29 patients with a sonographic diagnosis of bilateral polycystic kidney disease (PKD) were identified. Of these only 19 patients had their case notes traceable and were included in the study. The rest of the patients whose clinical records remained untraceable were excluded. From these records, demographic, clinical, and ultrasound scan data were extracted. The indices captured included the following: Age, sex, family history of renal cystic disease, history of hypertension and high blood pressure at diagnosis, comorbidity/clinical presentation, the latest ultrasound measurement of renal size (length and width), range of diameter of renal parenchymal cysts, presence or absence of extrarenal cysts, and patient outcome (See [Table 1]).
Table 1: The demographic, clinical and sonographic indices captured from patients' records


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   Results Top


A total of 19 patients with APKD were seen out of a total of 33,280 abdominal sonographic scans. Out of 19 patients, 12 were male and seven were female with a male to female ratio of 1:0.6. Overall age range was (31-79 years). The mean age of females was 50.9 ± 6.2 years (n = 7) and that of males was 57.2 ± 4.3 years (n = 12). The difference between the mean ages was 6.3 ± 7.4, which was found to be insignificant (P = 0.4, t = 0.85, Degree of freedom = 17). The clinical indications for ultrasonography included the following: Uremia, renal failure, benign prostatic hypertrophy, seizures, male infertility, allergy, inguinal hernia, anemia, and congestive cardiac failure. A few other patients presented for routine annual abdominal scans. At diagnosis, no family history of APKD was found in the records in 17 patients (89.5% of cases).

Hypertensive heart disease was a presenting feature in six (31.6%) of the total number of patients. The average systolic blood pressure among male and female hypertensive patients was 160 mmHg. Majority of those discovered to be hypertensive (66.7%) were males with an average systolic pressure of 165 mmHg, whereas among the females, 150 mmHg was the average systolic pressure. At presentation, three patients (15.7%) had already clinical and laboratory indices of renal failure. Sonographic assessment of patients' kidneys showed total mean renal size (renal length × renal width) to be 88.92 cm 2 for the right kidney and 98.97 cm 2 for the left kidney. Renal sizes for males and females were 92.2 and 83.3 cm 2 , respectively, for the right kidney and 105.5 and 91.8 cm 2 , respectively, for the left kidney. Mean renal cyst diameter in both sexes was 3.46 cm (range 2.08-4.85cm). In males, cyst diameter ranged from 2.09-4.58 cm. In females, the cyst diameter ranged from 2.04-5.31 cm (See [Table 2]). Only one patient (5.2%) had extrarenal cystic disease. Two patients (10.5%) were lost to renal and congestive cardiac failure.
Table 2: The mean renal sizes in male and female patients and the relative dimension of renal cysts


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   Discussion Top


Out of 33,280 patients referred for abdominal ultrasound scans, 29 adults were diagnosed with multiple bilateral renal parenchymal thin-walled cystic lesions consistent with polycystic kidney disease and 19 with traceable case notes eventually included in this study. In all the patients, none was clinically diagnosed, considering the known symptoms of APKD. [34] Furthermore, nothing in the patients' records suggested any prior patient knowledge of the renal condition. A total of 11 patients (58%) either came for routine abdominal scan with no specific complaints or had other symptoms unrelated to APKD [see [Table 1]]. Milutinovic et al., [35] in their series found 36% of patients with PKD to be asymptomatic, normotensive, and without previous problems. We observed that all the patients in our study presented late. While there was no significant difference between the ages of sexes at presentation, all had sonographically detectable mature renal cysts. This is not surprising as it is known that by the age of 30 years, 68% of patients with APKD will have visible cysts by ultrasound. [36] Apart from presenting late, none of the patients in our series presented any relatives for screening. This includes two patients who admitted to a positive family history of renal cystic disease. Of these two, one patient admitted that a first degree relative had died of complications from stroke. Across a spectrum of many disease conditions and social strata in the authors' locality, there exists a pervading trend of poor health-seeking behavior fuelled by economic constraints, fear, and local taboos, leading to late presentation. [37] In 1991, however, Onuigbo et al., [38] in one of the few family studies done in our locality found five siblings and the mother of an APKD patient to have sonologic features consistent with APKD, thus demonstrating the utility of premorbid ultrasound diagnosis.

Hypertension undoubtedly has an impact on the morbidity and mortality of patients with APKD. [22],[39] The incidence of hypertension was found to differ in various series. Differences appear to be due to the benchmark used by the various workers to define hypertension. [11],[35],[40],[41],[42],[43],[44],[45],[46],[47],[48] In spite of the relatively high mean age of 54.8 years in our series, hypertension was found only in about 32%. Other workers have detected hypertension in about 60% of patients with APKD long before diagnosis of frank renal impairment. [25],[26] Other APKD-related complications found in our series included congestive cardiac failure (5%), anemia (10%), and renal failure (16%). Two patient mortalities or 10.5% were recorded in our series. The causes of death were congestive cardiac failure and renal failure and the median age at demise was 65 years. It has long been established that the most common cause of death in patients with APKD is cardiovascular disease. [39] In a study by Rahman et al., [49] the most common cause of death stemmed from cardiovascular causes (46.6%) and median age at demise was 60.5 years. Intracranial aneurysms when they rupture result to subarachnoid bleed and have been described as the most devastating extrarenal complication of APKD, often resulting in premature death or disability. [24] Meanwhile, the prevalence of unruptured intracranial aneurysms is about 8% of the APKD population and is five times higher than the general population. [24] No record of a patient with intracranial aneurysm was found in our series. This is ostensibly because no Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) of the brain was done. Again, no records requesting either of these investigations as screening were found. For this reason, there were no data of the incidence of unruptured aneurysms among our patients.

While the use of ultrasonography without doubt played a crucial role in the detection of the renal cysts in our series, thus calling attention to the presence of an erstwhile clinically occult disease, no anteroposterior (AP) renal dimensions were available from records. For this reason, renal volume could not be calculated. The importance of renal volume lies in the fact that larger kidneys, linked to progressive increase in cyst volume [50] heralds worse prognosis in age-matched patients with APKD. [18] The increase in renal volume has thus been found to be a good prognostic index of renal impairment, even better than estimated glomerular filtration rate (eGFR) assays. [51]

Renal volume has been sonographically evaluated in health [52] and disease. [53] Studies suggest that renal volume determination using the ellipsoid method: Length (L) × width (W) × AP dimension ×0.523 [54] is better than renal length alone as potential surrogate marker of depressed renal function. [55] However, there exists considerable disagreement on the accuracy of two dimensional sonographically- determined renal volumes ostensibly due to claims of significant volume underestimation (as much as 25%). [56] Still, it is agreed that sonographic estimation of renal volume has a role to play where high exactitudes are not paramount as offered by volumetric methods available with CT and MRI. [27] Without doubt, in a resource-challenged setting such as ours that suffers from a dearth of the more profound modalities, sonographic estimation of renal volumes may continue to be useful.

Bilateral renal cysts found in all our patients exhibited marked size heterogeneity both within and between individual kidneys. While we offer no explanation for this observation, we note that other workers have made the same observations. [30],[31],[50] While males had larger renal sizes for either kidneys compared with females, females appeared to have larger average cyst sizes. Therefore, cyst size alone does not explain the disparity in renal sizes between male and female patients with APKD. Gender differences may have also contributed. Sex matching is therefore important in the evaluation and interpretation of renal size and renal cyst size.


   Conclusion Top


From our study it may appear that APKD is uncommon in our environment (prevalence, 0.7%); however, this may well be artifactual due to the observed local poor health-seeking behavior. It is therefore imperative that increased population and physician awareness be encouraged. Nonetheless, due to the importance of the kidneys to the body, the growing prevalence of renal- impairing disease [57] worldwide [12],[13] as well as in the authors' country [15],[16],[58] must be a source of concern. Further studies are required to showcase the contribution of APKD in renal and extrarenal morbidity. Because ultrasonography in a resource-challenged environment like ours will likely continue to play a role in the evaluation of the kidneys of APKD patients including renal volume determinations, AP renal dimensions should be routinely included to allow renal volumes to be calculated. Attending radiologists must be aware of the increased risk of intracranial aneurysms in patients with APKD. The potential devastation to patients, should rupture of these aneurysms occur, ought to galvanize more efforts toward ensuring that this extrarenal complication is screened.

Gender differences and not just cyst diameters may play a role in determining renal size in patients with APKD.

 
   References Top

1.
Neuman HP. The spectrum of renal cysts in adulthood- discussion of eight cases. Nephrol Dial Transplant 1999;14:2234-44.  Back to cited text no. 1
    
2.
Wilson PD. Polycystic kidney disease. N Engl J Med 2004;350:151-64.  Back to cited text no. 2
    
3.
Irazabal MV, Huston J 3 rd , Kubly V, Rosetti S, Sundsbak JL, Hogan MC, et al. Extended follow-up of unruptured intracranial aneurysms detected by presymptomatic screening in patients with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 2011;6:1274-85.  Back to cited text no. 3
    
4.
Thompson PD. Renal problems in black South African children. Paediatr Nephrol 1997;11:508-512.  Back to cited text no. 4
    
5.
Roberts OA, Shittu OB, Kadiri S. Polycystic kidney disease in pregnancy in a Nigerian woman. Trop J Obstet Gynaecol 2001;18:40-2.  Back to cited text no. 5
    
6.
Onuigbo WI. Comparative study of adult polycystic kidney disease. Ethiop Med J 2001;39:247-9.  Back to cited text no. 6
    
7.
Iglesias CG, Torres VE, Offord KP, Holey KE, Beard CM, Kurland LT. Epidemiology of adult polycystic kidney disease Olmsted County, Minesota: 1935-1980. Am J Kidney Dis 1983;2:630-639.  Back to cited text no. 7
    
8.
Bethseda ED. National Institute of Health National Institute of Diabetes and Digestive and Kidney diseases. The demographics of ESRD in USRDS, 1990 annual report; 1990. p.; 17-22.  Back to cited text no. 8
    
9.
Belibi FA, Edelstein CL. Unified ultrasonographic diagnostic criteria for polycystic kidney disease. J Am Soc Nephrol 2009;20:6-8.  Back to cited text no. 9
[PUBMED]    
10.
Okeahialam BN, Pam SD, Ekedigwe JE, Ekwempu CC. Familial polycystic kidney disease in Nigeria: A report of two cases. West Afr J Med 2006;25:249-51.  Back to cited text no. 10
    
11.
Chijioke A, Aderibigbe A, Olanrewaju TO, MakusidiAM, Oguntoyinbo AE, Braimoh KT. The prevalence and clinical characteristics of adult polycystic kidney disease in Ilorin, Nigeria. Port J Nephrol Hypert 2010:159-63.  Back to cited text no. 11
    
12.
WHO. The world health report 2003 - shaping the future. Geneva: World Health Organization; 2003  Back to cited text no. 12
    
13.
Beaglehole R, Yach D. Globalisation and the prevention and control of non-communicable diseases: The neglected chronic disease of adults. Lancet 2003;362: 903-8.  Back to cited text no. 13
    
14.
National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney diseases: Evaluation, classification and stratification. Am J Kidney Dis 2002;39:S1-226.  Back to cited text no. 14
[PUBMED]    
15.
Akinsola W, Odesanmi WO, Oguniyi JO, Ladipo GO. Diseases causing renal failure in Nigerians- A prospective study of 100 cases. Afr J Med Sci 1989;18:131-7.  Back to cited text no. 15
    
16.
Nwankwo EA, Nwankwo B, Mubi B. Prevalence of impaired kidney function in hospitalised hypertensive patients in Maiduguri, Nigeria. Internet J Internal Med 2006;6.  Back to cited text no. 16
    
17.
Gabow PA. Autosomal dominant polycystic kidney disease. N Engl J Med 1993;329:332-42.  Back to cited text no. 17
    
18.
Grantham JJ, Chapman AB, Torres VE. Volume progression in autosomal dominant polycystic kidney disease: The major factor determining clinical outcomes. Clin J Am Soc Nephrol 2006;1:148-57.  Back to cited text no. 18
    
19.
Grantham J, Cowley BJ, Torres VE.Progression of autosomal dominant polycystic kidney disease (ADPKD) to renal failure. In: Seldin DW, Giebisch G, editors. The Kidney: Physiology and Pathophysiology. Vol. 2. Philadelphia: Lippincott Williams and Wilkins; 2000. p.2513-2536.  Back to cited text no. 19
    
20.
Choukroun G, Itakura Y, Albouze G, Christophe JL, Man NK, Grünfeld JP, Jungers P. Factors influencing progression of renal failure in autosomal dominant polycystic kidney disease. J AmSoc Nephrol 1995;6:1634-42.  Back to cited text no. 20
    
21.
Grantham JJ. Mechanisms of progression in autosomal dominant polycystic kidney disease. Kidney Int Suppl 1997;63:S93-7.  Back to cited text no. 21
    
22.
Gabow PA, Johnson AM, Kaehny WD, Kimberling WJ, Lezotte DC, Duley IT, et al. Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease. Kidney Int 1992;41:1311-9.  Back to cited text no. 22
    
23.
Chapman AB. Cystic disease in women: Clinical characteristics and medical management. Adv Ren Replace Ther 2003;10:24-30.  Back to cited text no. 23
    
24.
Pirson Y, Chauveau D, Torres VE. Management of cerebral aneurysms in autosomal dominant polycystic kidney disease.: JAm Soc Nephrol 2002;13:269-76.  Back to cited text no. 24
    
25.
Chapman AB, Schrier RW. Pathogenesis of hypertension in autosomal dominant polycystic kidney disease. Semin Nephrol 1991;11:653-60.  Back to cited text no. 25
    
26.
Gabow PA, Chapman AB, Johnson AM, Tangel DJ, Duley IT, Kaehny WD, et al. Renal structure and hypertension in autosomal dominant polycystic kidney disease. Kidney Int 1990;38:1177-80.  Back to cited text no. 26
    
27.
Kondo A, Akakura K, Ito H. Assessment of renal function with colour Doppler ultrasound in autosomal dominant polycystic kidney disease. Int J Urol 2001;8:95-8.  Back to cited text no. 27
    
28.
Nicolau C, Torra R, Bianchi L, Vilana R, Gilabert R, Darnell A, et al. Abdominal sonographic study of autosomal dominant polycystic kidney disease. J Clin Ultrasound 2000;28:277-82.  Back to cited text no. 28
    
29.
Pei Y, Obaji J, Dupuis A, Paterson AD, Magistroni R, Dicks E, et al. Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol 2009;20:205-12.  Back to cited text no. 29
    
30.
King BF, Reed JE, Bergstralh, EJ, Sheedy PF 2 nd , Torres VE. Quantification and longitudinal trends of kidney, renal cyst, and renal parenchymal volumes in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 2000;11:1505-11.  Back to cited text no. 30
    
31.
Sise C, Kusaka M, Wetzel LH, Winklhofer F, Cowley BD, Cook LT, et al. Volumetric determination of progression in autosomal dominant polycystic kidney disease by computed tomography. Kidney Int 2000;58:2492-501.  Back to cited text no. 31
    
32.
Fick-Brosnahan GM, Belz MM, McFann KK, Johnson AM, Schrier RW. Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: A longitudinal study. Am J Kidney Dis 2002;39:1127-34.  Back to cited text no. 32
    
33.
Thomsen HS, Madsen JK, Thaysen JH, Damgaard-Petersen K. Volume of polycystic kidneys during reduction of renal function. Urol Radiol 1981;3:85-9.  Back to cited text no. 33
[PUBMED]    
34.
Morcos SK. Non-neoplastic renal cystic disease. In: Morcos SK, Thomsen HS, editors. Urogenital Imaging: A Problem-Oriented Approach. 1 st ed. Chichester: John Wiley & Sons Ltd.; 2009. p. 75-97.  Back to cited text no. 34
    
35.
Milutinovic J, Fialkow PJ, Agodoa LY, Phillips LA, Rudd TG, Bryant JI. Autosomal dominant polycystic kidney disease: Symptoms and clinical findings. Q J Med 1984;53:511-22.  Back to cited text no. 35
    
36.
Nahm AM, Henriquez DE, Ritz E. Renal cystic disease (ADPKD and ARPKD). Nephrol Dial Transplant 2002;17:311-4.  Back to cited text no. 36
    
37.
Ibrahim NA, Oludara MA. Socio-demographic factors and reasons associated with delay in breast cancer presentation: A study in Nigerian women. Breast 2012;21:416-8.  Back to cited text no. 37
    
38.
Onuigbo MA, Ozoh JO, Egbuji T, Ijeoma CK, Chukwuka C, Offodile AA, et al. Adult Polycystic Kidney Disease: A Nigerian family study. Niger Med J 1991;21:71-3.  Back to cited text no. 38
    
39.
Fick GM, Johnson AM, Hammond WS, Gabow PA. Causes of death in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1995;5:2048-56.  Back to cited text no. 39
    
40.
Ecder T, Schrier RW. Hypertension in autosomal-dominant polycystic kidney disease: Early occurrence and unique aspects. J Am Soc Nephrol 2001;12:194-200.  Back to cited text no. 40
    
41.
Braasch WF. Clinical data of polycystic kidney.Surg Gynecol Obstet 1916;23:697-702.  Back to cited text no. 41
    
42.
Scacht FW. Hypertension in cases of congenital polycystic kidney.Arch Intern Med (Chic) 1931;47:500-9.  Back to cited text no. 42
    
43.
Rall JE, Odel HM. Congenital polycystic disease of the kidney; review of the literature and data on 207 cases. Am J Med Sci 1949;218:399-407.  Back to cited text no. 43
[PUBMED]    
44.
Dalgaard OZ. Bilateral polycystic disease of the kidneys; a follow-up of two hundred and eighty-four patients and their families. Acta Med Scand Suppl 1957;328:1-255.  Back to cited text no. 44
[PUBMED]    
45.
Hansson L, Karlander LE, Lundgren W, Peterson LE. Hypertension in polycystic kidney disease. Scand J Urol Nephrol 1974;8:203-5.  Back to cited text no. 45
[PUBMED]    
46.
Calabrese G, Vagelli G, Cristofano C, Barsotti G. Behaviour of arterial pressure in different stages of polycystic kidney disease. Nephron 1982;32:207-8.  Back to cited text no. 46
[PUBMED]    
47.
Gabow PA, Iklé DW, Holmes JH. Polycystic kidney disease: Prospective analysis of nonazotemic patients and family members. Ann Intern Med 1984;101:238-47.  Back to cited text no. 47
    
48.
Fick GM, Duley IT, Johnson AM, Strain JD, Manco-Johnson ML, Gabow PA. The spectrum of autosomal dominant polycystic kidney disease in children. J Am Soc Nephrol 1994;4:1654-60.  Back to cited text no. 48
    
49.
Rahman E, Niaz FA, Al-Suwaida A, Nahrir S, Bashir M, Rahman H, et al. Analysis of causes of mortality in patients with autosomal dominant polycystic kidney disease: A single centre study. Saudi J Kidney Dis Transpl 2009;20:806-10.  Back to cited text no. 49
[PUBMED]  Medknow Journal  
50.
Grantham JJ, Torres VE, Chapman AB, Guay-Woodford LM, Bae KT, King BF Jr, et al. CRISP Investigators Volume progression in polycystic kidney disease. N Engl J Med 2006;354:2122-30.  Back to cited text no. 50
    
51.
Rule AD, Torres VE, Chapman AB, Grantham JJ, Guay-Woodford LM, Bae KT, et al. CRISP Consortium. Comparison of methods for determining renal function decline in early autosomal dominant polycystic kidney disease: The consortium of radiologic imaging studies of polycystic kidney disease cohort. J Am Soc Nephrol 2006;17:854-62.  Back to cited text no. 51
    
52.
Kim JH, Kim MJ, Lim SH, Kim J, Lee MJ. Length and volume of morphologically normal kidneys in Korean Children: Ultrasound measurement and estimation using body size. Korean J Radiol 2013;14:677-82.  Back to cited text no. 52
    
53.
Egberongbe AA, Adetiloye VA, Adeyinka AO, Afolabi OT, Akintomide AO, Ayoola OO. Evaluation of renal volume by ultrasonography in patients with essential hypertension in Ile-Ife, south western Nigeria. Libyan J Med 2010:5.  Back to cited text no. 53
    
54.
Hricak H, Lieto RP. Sonographic determination of renal volume. Radiology 1983;148:311-2.  Back to cited text no. 54
[PUBMED]    
55.
Widjaja E, Oxtoby JW, Hale TL, Jones PW, Harden PN, McCall IW. Ultrasound measured renal length versus low dose CT volume in predicting single kidney glomerular filtration rate. Br J Radiol 2004;77:759-64.  Back to cited text no. 55
    
56.
Bakker J, Olree M, Kaatee R, de Lange EE, Moons KG, Beutler JJ, et al. Renal volume measurements: Accuracy and repeatability of US compared with that of MR imaging. Radiology 1999;211:623-8.  Back to cited text no. 56
    
57.
Schena FP. Epidemiology of end-stage renal disease: International comparisons of renal replacement therapy. Kidney Int 2000;57: S39-45.  Back to cited text no. 57
    
58.
Abioye-Kuteyi EA, Akinsola A, Ezeoma IT. Renal disease: The need for community-based rural screening in rural Nigeria. Afr J Med Pract 1999;6:198-201.  Back to cited text no. 58
    


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