Medical and Dental Consultantsí Association of Nigeria
Home - About us - Editorial board - Search - Ahead of print - Current issue - Archives - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 429   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

  Table of Contents 
Year : 2018  |  Volume : 21  |  Issue : 9  |  Page : 1213-1220

The effects of psychostimulants on oral health and saliva in children with attention deficit hyperactivity disorder: A case-control study

1 Department of Pediatric Dentistry, School of Dentistry, Pamukkale University, Denizli, Turkey
2 Department of Pediatric Dentistry, School of Dentistry, Süleyman Demirel University, Isparta, Turkey
3 Department of Child and Adolescent Psychiatry, School of Medicine, Süleyman Demirel University, Isparta, Turkey
4 Department of Medical Biochemistry, School of Medicine, Alanya Alaaddin Keykubat University, Antalya, Turkey

Date of Acceptance27-Apr-2018
Date of Web Publication29-Aug-2018

Correspondence Address:
Dr. C C Ertugrul
Department of Paediatric Dentistry, Pamukkale University, Faculty of Dentistry, Denizli
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njcp.njcp_385_17

Rights and Permissions

Introduction: This study investigated the dental health problems and saliva characteristics of children under psychostimulant therapy for attention-deficit hyperactivity disorder (ADHD). Materials and Methods: One hundred and twenty children aged 7–12 years were divided into three groups. Groups 1–2 comprised children diagnosed with ADHD: those who had not yet started psychostimulant therapy (Group 1) and those already receiving long-term psychostimulant therapy (Group 2). Group 3 comprised healthy, nonmedicated children. Possible side effects of psychostimulants were investigated at the beginning of study in Group 2 and after 3 months drug use in Group 1. Bruxism and dental erosion prevalence, salivary Streptococcus mutans count, buffering capacity, and stimulated salivary flow rate (SSFR) were measured, and salivary α-amylase, calcium, total protein, and proline-rich acidic protein (PRAP) levels were quantified in the beginning of the study. Data were analyzed using the Kruskal–Wallis test. Results: The most frequently reported side effects of psychostimulants were decreased appetite, dry mouth, and increased fluid consumption. The prevalence of bruxism and dental erosion was higher in Groups 1 and 2 than in Group 3, but the differences were not significant (P > 0.05). In Group 2, subjective dry mouth feel was reported by 32.5% of patients and 17.5% had a very low SSFR. Salivary α-amylase, calcium, total protein, and PRAP levels were lower in Group 2 than the others, but the differences were not significant (P > 0.05). Conclusions: ADHD and psychostimulant therapy do not appear to be significantly related to decreasing SSFR or protective saliva components against dental caries. However, a systematic investigation of the long-term safety of psychostimulants is needed. The most effective method of maintaining dental health of children with ADHD is frequent appointments focusing on oral hygiene practices accompanied by dietary analyses.

Keywords: Attention-deficit hyperactivity disorder, bruxism, dental erosion, dry mouth, psychostimulants, saliva biochemical components, salivary flow rate

How to cite this article:
Ertugrul C C, Kirzioglu Z, Aktepe E, Savas H B. The effects of psychostimulants on oral health and saliva in children with attention deficit hyperactivity disorder: A case-control study. Niger J Clin Pract 2018;21:1213-20

How to cite this URL:
Ertugrul C C, Kirzioglu Z, Aktepe E, Savas H B. The effects of psychostimulants on oral health and saliva in children with attention deficit hyperactivity disorder: A case-control study. Niger J Clin Pract [serial online] 2018 [cited 2020 Jul 7];21:1213-20. Available from:

   Introduction Top

Attention-deficit hyperactivity disorder (ADHD) is a childhood psychiatric disorder characterized by inattention, hyperactivity, and impulsivity.[1] ADHD has been reported to be among the most frequent diagnoses in patients referred to child psychiatry clinics worldwide, and male children are affected more than the females.[2],[3],[4] Psychostimulants are currently the most commonly used psychotropic drugs to treat ADHD in psychiatric patients under the age of 18 years, and psychostimulant usage has increased in recent years.[5],[6]

Numerous studies describe several side effects of psychostimulants that threaten oral and dental health, including dry mouth, gingival overgrowth, dental erosion, awake bruxism, and sleep bruxism.[7] It was reported that signs and symptoms of temporomandibular joint dysfunction may be influenced by the use of medications prescribed for ADHD.[8] In a recent systematic review, psychostimulants were shown to induce xerostomia, salivary gland hypofunction, and sialorrhea.[9] In children and young adults with ADHD, unstimulated salivary flow rate (SSFR) was found to be lower, and microbial dental plaque scores were higher than non-ADHD[10] Obtained data from current research such as inappropriate oral health behaviors, excessive consumption of sugary snacks and beverages, and an increased number of meals in children with ADHD suggest that ADHD may be a risk factor for the development of dental decay.[10],[11],[12],[13],[14] It was concluded in a study that the risk of dental caries is higher in children with attention deficits independently of their socioeconomic status than in healthy children.[15] In such instances, protective properties of saliva become pivotal in preventing tooth decay and gum diseases. When the saliva flow rate is decreased, there may be changes in the organic and inorganic components of the saliva (e.g., proteins, enzymes, and calcium), which are responsible for protecting enamel integrity.[10] Furthermore, the biochemical composition of saliva may be directly affected by the side effects of psychotropic drugs.[16],[17] Furthermore, some researchers found that there is a significant increase in the salivary protein thiols and pseudocholinesterase levels in ADHD children when compared to controls.[18] However, few studies have clinically investigated these effects of psychotropic drugs in school-aged children with ADHD.

The focus of this study is to decide if any evidence exists to verify that ADHD itself or stimulant therapy in children threatens the oral and dental health by virtue of its effects on the saliva physical and biochemical properties. The authors hypothesized that salivary flow rate, pH, buffering capacity, and salivary biochemical components which are responsible for protecting tooth tissues from decay in ADHD children medicated with psychostimulants are lower than in nonmedicated ADHD children and healthy controls. Furthermore, the hypotheses that the prevalence of bruxism and dental erosion is higher in ADHD children with or without medication than healthy peers are tested. By the virtue of obtained data, it was aimed to determine the measures must be taken to maintain dental health of children with ADHD.

   Materials and Methods Top

Study population

The study protocol was approved by the Clinical Research Ethics Committee of the Medical Faculty (No. 173/2014). Informed consent was obtained from parents of all children who participated in the study. The children with ADHD had been diagnosed based on inattention, hyperactivity, and impulsivity symptoms as described in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition[1] and treated by child psychiatrists in the Child and Adolescent Psychiatry Department of Medical School.

A total of 120 children, aged 7–12 years, were divided into three groups of 40 each. Groups 1 and 2 comprised children diagnosed with ADHD: those about to start psychostimulant therapy (Group 1) and those already under long-term (≥6 months) psychostimulant therapy (Group 2). Group 3 comprised healthy, nonmedicated children (control group). Inclusion criteria were as follows: (1) Patients in Groups 1 and 2 were diagnosed with ADHD and did not have any disorders other than ADHD. (2) In Group 2, no other medication than psychostimulants were taken. (3) Children in the control group were healthy and did not use any medication regularly in the month before the study. Exclusion criteria were as follows: (1) Exposure to any infection that could cause dehydration in the 1 month before the saliva analysis. (2) Use of antibiotics in the 3 weeks before the analysis. (3) Topical application of fluoride in the last 48 h before analysis. (4) Gingival bleeding. (5) Fixed or removable appliance or a dental crown in the mouth.

Study design

The flow chart of the study is as follows:

  • Medical history and medication data for all participants were gathered from Child Psychiatry Department records
  • Parents of children were questioned regarding possible psychostimulant side effects such as appetite changes, thirst or dry mouth, and increased consumption of liquid (water, soft drinks) in Group 1 after 3 months drug use and in Group 2 at the beginning of the study
  • Information was obtained from all parents on whether their children were experiencing either awake or sleep bruxism
  • Children's behavior during dental examinations was scored according to the Frankl behavior scale (1: Definitely negative, 2: Negative, 3: Positive, 4: Definitely positive)[19]
  • Intraoral examinations were performed based on oral health surveys and basic methods specified by the World Health Organization,[20] and dental erosion scores were recorded by the basic erosive wear examination (BEWE) scoring system.[21] For grading erosive wear of each tooth, four scores (Score 0:no erosive tooth wear, Score 1:initial loss of surface texture, Score 2:distinct defect, hard tissue loss is less than 50% of the surface area, Score 3: hard tissue loss is more than 50% of the surface area) are used in this scoring system. After the estimation of dental scores the individual risk of erosive tooth wear (none, low, medium, high) is determined for each patient.[21]
  • Quantifying of salivary Streptococcus mutans count with the Saliva-Check Mutans test (GC Europe N. V. Leuven, Belgium)
  • Collection and storage of unstimulated saliva samples for biochemical analysis of salivary amylase, calcium, total protein, and proline-rich acidic protein (PRAP). Unstimulated saliva was obtained by asking children to collect saliva in their mouths and spit it into a test tube
  • Measurement of saliva viscosity, pH, and buffering capacity from unstimulated saliva samples with Saliva-Check Buffer test (GC Europe N. V. Leuven, Belgium). Salivary viscosity was evaluated by visually assessing the resting salivary consistency in the oral cavity in accordance with the instructions of the manufacturers. Salivary pH and buffering capacity were measured with stripes from test content
  • Collection of stimulated saliva samples by having the children chew paraffin gum for 5 min and spit into a scaled cup and measurement of SSFR
  • Saliva analyses were performed at the beginning of the study in all groups. To avoid possible effects of circadian rhythm, saliva was collected from all participants under the same conditions between 09:00 AM and 11:00 AM. Children refrained from eating, drinking, brushing teeth, and rinsing for at least 2 h before saliva analyses.

A flat polyethylene tube with absorbent cotton and screw cap (Salivette®, Sarstedt AG and Co., Nümbrecht, Germany) was used for biochemical analyses. The absorbent cotton in the tube was not used because it can stimulate the flow of saliva. For biochemical analyses, the tubes of saliva samples were stored at −80°C (Wise Cryo. Aachen, Germany). Before the analyses, the samples were thawed, cool centrifuged at 4000 g for 4 min (Eppendorf MR5415, Wesseling-Berzdorf, Germany), and the supernatants were then separated into aliquots. The levels of salivary α-amylase, calcium, and total protein were measured using a colorimetric assay kit (Beckman Coulter, Brea CA, USA) and an autoanalyzer device (AU 5800; Beckman Coulter). The PRAP measurement was made using a human PRAP1 enzyme-linked immunosorbent assay kit (Hangzhou Eastbiopharm Co., Ltd., Hangzhou, China).

Statistical analysis

All data were entered into the SPSS Statistics Version 20.0 software package (IBM, SPSS Inc., USA). The Chi-square independence test was applied for nominal data. The Kruskal–Wallis test was used to evaluate differences between groups because the data did not satisfy the preconditions for parametric tests. As a result of the Kruskal–Wallis test, differences between the medians of groups were evaluated using the Bonferroni–Dunn test.

   Results Top

Mean ages of the children participated in the study were 8.81 ± 1.83 (Group 1), 9.07 ± 1.44 (Group 2), 8.78 ± 1.38 (Group 3), and there was no statistically significant difference in gender between the groups (P > 0.05).

All patients in Groups 1 and 2 were prescribed methylphenidate. Only 14 patients (35%) in Group 1 began and continued to use methylphenidate for 3 months; 26 of them began but stopped drug therapy after a few doses because of various reasons. The most common parent-reported side effects of methylphenidate were decreased appetite, increased fluid consumption, and feeling of dry mouth, respectively. Subjective dry mouth feel was reported by 32.5% of the children in Group 2, and 42.5% of the children in this group have been found to increase fluid consumption. Data on patients with drug side effects in Group 1 after 3-month usage and Group 2 are presented in [Table 1].
Table 1: Patients with drug side effects in attention-deficit hyperactivity disorder groups

Click here to view

Mean Frankl behavior scale scores were 3.44 ± 0.65 (Group 1), 3.36 ± 0.73 (Group 2), 3.90 ± 0.30 (Group 3), and significantly lower in both Group 1 and Group 2 (P = 0.000) than in Group 3.

Awake bruxism is most frequently seen in Group 1 (20%), and sleep bruxism is the most frequently seen in Group 2 (32.5%). The prevalences of awake and sleep bruxism in Group 1 and Group 2 were higher than those in Group 3, but the differences were not statistically significant (P > 0.05) [Table 2]. The highest BEWE index scores were found in Group 2. Mean BEWE index score of Group 1 (0.75 ± 0.76) and Group 2 (0.73 ± 0.59) were higher than Group 3 (0.51 ± 0.67) although the difference was not significant (P = 0.161). BEWE findings of the study are presented in [Table 3].
Table 2: The prevalence of awake and sleep bruxism in each group

Click here to view
Table 3: Basic erosive wear examination findings of the groups

Click here to view

The saliva S. mutans count was higher than 5 × 105 CFU/mL, which indicates the high caries risk in all children participated in the study. The highest salivary viscosity and lowest salivary flow rate and buffering capacity values were measured in Group 2. However, differences in salivary viscosity (P = 0.350), pH (P = 0.055), flow rate (P = 0.249), and buffering capacity (P = 0.406) among the groups were not statistically significant. Salivary viscosity, pH, SSFR, and buffering capacity values are presented in [Table 4].
Table 4: Salivary viscosity, pH, stimulated salivary flow rate, and buffering capacity findings of the groups

Click here to view

Salivary biochemical analyses were performed on 20 saliva samples in each cohort. The lowest median values of α-amylase, calcium, total protein, and PRAP were determined in Group 2, and the highest median values of α-amylase, calcium, and total protein were in control group. However, the differences in evaluated biochemical components of the saliva between all groups were not statistically significant (P > 0.05) [Table 5].
Table 5: Salivary biochemical analysis findings in each group

Click here to view

   Discussion Top

The number of ADHD cases and the use of psychostimulant therapy have increased in recent years, but the literature remains unclear both on the short-/long-term drug side effects and the impact of the disease on the dental health of the children.

It has been reported that the majority of patients referred to the Child Psychiatry Clinics range in age from 7 to 12 years.[22],[23] In pediatric dentistry, school age (7–12 years) is a period when nutrition and toothbrushing habits decline, while elements that threaten anatomical and physiological aspects of dental health increase. Therefore, the current study included children aged 7–12 years. The majority of children with ADHD in our study group were male (82.5%), in concurrence with the literature.[2],[4]

Due to the characteristic symptoms of the disease, such as overactivity and impulsivity, children with ADHD may have difficulties in interacting with the dentist and in staying focused on dental procedures, and so the dental treatments could be challenging.[24],[25] However, children with ADHD and healthy children are reported to experience similar levels of dental anxiety.[26] In the present study, children in Groups 1 and 2 were found to have difficulty in communicating with the dentist during the dental examinations, and the Frankl scale scores of these children were significantly lower than were those of the control group. Furthermore, treatment of some ADHD patients was often delayed or completed under sedation.

Side effects of psychostimulant drugs are frequently discussed in the literature.[9],[27] Some authors have reported that methylphenidate causes subjective dry mouth,[28] while others have not found any effect on salivary flow rate.[29],[30] Wolff et al. (2017) reported in a recent study that psychostimulants induce xerostomia.[9] In the present study, we found that 32.5% of children receiving long-term methylphenidate use had subjective dry mouth and that 17.5% had a markedly low SSFR level (<0.7 ml/min). At the beginning of the study, it was hypothesized that the SSFRs of medicated ADHD children are lower than those of not yet on medication ADHD cases and of healthy controls. The similar measurement of SSFRs in Groups 1 and 2 weakened the opinion that methylphenidate may cause xerostomia.[31] The findings of Medori et al. that children with ADHD using methylphenidate have more cases of xerostomia than the control group were based on subjective complaints of participants.[31] In contrast, this study objectively measured the amount of stimulated saliva.

In this study, saliva pH, viscosity, and buffering capacity were similar in all three groups. This finding is compatible with the results of a similar study by Hidas et al.[12] Hence, it is not possible to conclude that medicated ADHD children are at a dental disadvantage compared with nonmedicated ADHD children or those without ADHD, based on salivary pH, viscosity, and buffer capacity, which are the major mechanisms by which saliva protects against tooth decay.

Salivary defense systems including salivary calcium, total proteins, and PRAP play significant roles in maintaining the health of the oral cavity and preventing caries.[29],[32],[33],[34] It has been reported that PRAP levels are significantly correlated with lower caries scores.[29] In addition, salivary amylase is one of the building blocks of the acquired pellicle and therefore serves as a receptor for the adhesion of microorganisms to the tooth surface.[35],[36] Moreover, α-amylase levels have gained increasing interest as indicators of bodily changes following stress, specifically under autonomic activation.[37] However, a low salivary flow rate can alter the biochemical composition of saliva.[38] In addition, some psychotropic drugs have also been reported to change salivary biochemical content.[16],[17],[18] To the best of our knowledge, no prior study has investigated the effect of stimulant drugs on salivary amylase, calcium, total protein, and PRAP in children with ADHD. The current investigation found that the salivary calcium, total protein, and PRAP levels were lower in children who used psychostimulants on a long-term basis than in the other groups. This could indicate that these children, particularly those with low salivary flow rates, may be susceptible to tooth decay, but further researches are needed about this subject.

Another commonly reported side effect of psychostimulants is bruxism. Investigations have shown that bruxism can be pharmacologically modulated by substances that act on the neurotransmission of the brain, supporting the concept that bruxism is primarily a central nervous system phenomenon.[39],[40],[41] Some studies suggest that the prevalence of bruxism is higher in children with ADHD than in those without ADHD and that bruxism can occur as a side effect of stimulant therapy.[42],[43],[44] A recent study concluded that ADHD signs had a significant effect on sleep bruxism in school-age children.[45] Chau et al. found that children with ADHD had a significantly higher frequency of parent-reported bruxism than did children without ADHD.[30] Another investigation showed that medicated ADHD children were more likely to develop bruxism than were nonmedicated children with ADHD or children in the control group.[43] The same study found that the number of worn teeth was 2.5 times higher in the children who used psychostimulants than in those who did not.[43] However, Hidas et al. found no significant difference between children with ADHD and healthy children in the prevalence of bruxism.[10] Our study showed that the prevalence of bruxism was higher in Groups 1 and 2 than in the control group, but the differences were not statistically significant for either awake or sleep bruxism. In addition, the similar prevalences of bruxism in Groups 1 and 2 suggest that bruxism may occur due to the neuropsychiatric disease itself, rather than to drug side effects.

There are few studies in the literature investigating the prevalence of dental erosion, which has been reported to be a side effect of psychostimulant therapy in children with ADHD. Chau et al. found no significant differences in tooth wear between children with and without ADHD.[30] In the present study, dental erosion was found to be higher in Groups 1 and 2 than in the control group, but it was thought that the number of eroded teeth may be increased because of the higher prevalence of bruxism in these groups. Furthermore, in our study, the high prevalence of dental erosion in ADHD patients who did not use psychostimulants yet was similar to that of psychostimulant users, weakening the argument that dental erosion may be a side effect of psychostimulant therapy. However, dry mouth, one of the reported side effects of the psychostimulants, has been associated with increased frequency of consumption of acidic beverages and poor oral hygiene.[46] Therefore, it should be considered that children with ADHD who have dry mouths and/or reduced salivary flow rates may be at high risk for dental erosion and caries.

All children in the study recorded high counts (≥5.105 CFU/mL) of salivary S. mutans, one of the most important etiological factors of dental caries. Even though children with ADHD had S. mutans counts that were similar to those of healthy children, children with ADHD have been found to be at high risk of caries and should have regular dental examinations.[15],[47]

The literature remains inconclusive regarding the dental effects of ADHD and its related factors. A systematic investigation of the long-term safety of psychostimulant drugs is needed. The current opinion is that ADHD children have lower un-SSFRs, worse oral health behaviors, higher plaque indices, and more frequent snacking habits than do children without ADHD.[10],[12]

The most effective methods for maintaining dental and oral health in ADHD children are more frequent appointments focusing on home oral hygiene practices and dietary analyses to reduce the consumption of cariogenic foods and beverages. In one study, parents of children with developmental disorders such as ADHD reported that their children's oral and dental health care needs were not adequately satisfied.[48] As did previous investigations, our study indicated that dental treatment for ADHD children should include an understanding of their behavior management needs. Children with ADHD are considered patients who need special attention in pediatric dentistry. Increased awareness is needed regarding ADHD and the dental health problems of ADHD patients, as is coordination between child psychiatrists and pediatric dentists.

Limitations of the study

This study was also intended to compare the initial and 3-month salivary analysis findings of children in Group 1. However, for various reasons, the parents did not fully support their children's medication regimens. Consequently, most (65%) of the children discontinued medication before 3 months. Thus, saliva evaluations could only be performed at the beginning in Group 1, not after 3 months of drug use as intended.

   Conclusions Top

This study found that methylphenidate use had no significant effect on salivary pH, stimulated flow rate, buffering capacity, or biochemical content of the saliva. Bruxism and dental erosion prevalence were higher in the ADHD groups, but the findings were not statistically significant. ADHD and psychostimulant therapy do not appear to be significantly responsible for decreased salivary flow rates or changes in saliva pH, viscosity, buffering capacity, or examined biochemical components. However, further studies with larger samples are needed to clarify alterations in saliva characteristics of children with ADHD, as well as to confirm previous findings regarding the possible side effects of psychostimulant drug use in children.


We are thankful to Asst. Prof. Dr. Özgür Koşkan for the statistical analyses of the study.

There are no conflicts of interest.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington DC: American Psychiatric Association; 2000.  Back to cited text no. 1
Wamulugwa J, Kakooza A, Kitaka SB, Nalugya J, Kaddumukasa M, Moore S, et al. Prevalence and associated factors of attention deficit hyperactivity disorder (ADHD) among Ugandan children; a cross-sectional study. Child Adolesc Psychiatry Ment Health 2017;11:18.  Back to cited text no. 2
Karanges EA, Stephenson CP, McGregor IS. Longitudinal trends in the dispensing of psychotropic medications in Australia from 2009-2012: Focus on children, adolescents and prescriber specialty. Aust N Z J Psychiatry 2014;48:917-31.  Back to cited text no. 3
Staller JA. Diagnostic profiles in outpatient child psychiatry. Am J Orthopsychiatry 2006;76:98-102.  Back to cited text no. 4
Staller JA, Wade MJ, Baker M. Current prescribing patterns in outpatient child and adolescent psychiatric practice in central New York. J Child Adolesc Psychopharmacol 2005;15:57-61.  Back to cited text no. 5
Boland F, Galvin R, Reulbach U, Motterlini N, Kelly D, Bennett K, et al. Psychostimulant prescribing trends in a paediatric population in İreland: A national cohort study. BMC Pediatr 2015;15:118.  Back to cited text no. 6
Fratto G, Manzon L. Use of psychotropic drugs and associated dental diseases. Int J Psychiatry Med 2014;48:185-97.  Back to cited text no. 7
Drisdale Iii JK, Thornhill MG, Vieira AR. Specific central nervous system medications are associated with temporomandibular joint symptoms. Int J Dent 2017;2017:1026834.  Back to cited text no. 8
Wolff A, Joshi RK, Ekström J, Aframian D, Pedersen AM, Proctor G, et al. A guide to medications inducing salivary gland dysfunction, xerostomia, and subjective sialorrhea: A systematic review sponsored by the world workshop on oral medicine VI. Drugs R D 2017;17:1-28.  Back to cited text no. 9
Hidas A, Noy AF, Birman N, Shapira J, Matot I, Steinberg D, et al. Oral health status, salivary flow rate and salivary quality in children, adolescents and young adults with ADHD. Arch Oral Biol 2011;56:1137-41.  Back to cited text no. 10
Blomqvist M, Ahadi S, Fernell E, Ek U, Dahllöf G. Dental caries in adolescents with attention deficit hyperactivity disorder: A population-based follow-up study. Eur J Oral Sci 2011;119:381-5.  Back to cited text no. 11
Hidas A, Birman N, Noy AF, Shapira J, Matot I, Steinberg D, et al. Salivary bacteria and oral health status in medicated and non-medicated children and adolescents with attention deficit hyperactivity disorder (ADHD). Clin Oral Investig 2013;17:1863-7.  Back to cited text no. 12
Kohlboeck G, Heitmueller D, Neumann C, Tiesler C, Heinrich J, Heinrich-Weltzien R, et al. Is there a relationship between hyperactivity/inattention symptoms and poor oral health? Results from the GINIplus and LISAplus study. Clin Oral Investig 2013;17:1329-38.  Back to cited text no. 13
Staberg M, Norén JG, Johnson M, Kopp S, Robertson A. Parental attitudes and experiences of dental care in children and adolescents with ADHD – A questionnaire study. Swed Dent J 2014;38:93-100.  Back to cited text no. 14
Mota-Veloso I, Pordeus IA, Homem MA, Ramos-Jorge J, Oliveira-Ferreira F, Ramos-Jorge ML, et al. Do signs of attention-deficit/hyperactivity disorder increase the odds of dental caries? A case-control study. Caries Res 2018;52:212-9.  Back to cited text no. 15
von Knorring L, Mörnstad H. Saliva secretion rate and saliva composition as a model to determine the effect of antidepressant drugs on cholinergic and noradrenergic transmission. Neuropsychobiology 1986;15:146-54.  Back to cited text no. 16
Milton BA, Bhambal A, Nair P. Sialochemical analysis: Windfall to the oral physician A hospital-based clinical cross-sectional study in depressive disorders. J Int Oral Health 2014;6:82-9.  Back to cited text no. 17
Archana E, Pai P, Prabhu BK, Shenoy RP, Prabhu K, Rao A, et al. Altered biochemical parameters in saliva of pediatric attention deficit hyperactivity disorder. Neurochem Res 2012;37:330-4.  Back to cited text no. 18
Frankl S, Shiere F, Fogels H. Should the parent remain with the child in the dental operatory. J Dent Child 1962;29:150-62.  Back to cited text no. 19
World Health Organization. Oral Health Surveys: Basic Methods. 5th ed. Geneva: World Health Organization; 2013. p. 35-55.  Back to cited text no. 20
Bartlett D, Ganss C, Lussi A. Basic Erosive Wear Examination (BEWE): A new scoring system for scientific and clinical needs. Clin Oral Investig 2008;12 Suppl 1:S65-8.  Back to cited text no. 21
Durukan İ, Karaman D, Kara K, Türker T, Tufan AE, Yalçın Ö, et al. Diagnoses of patients referring to a child and adolescent psychiatry outpatient clinic. The Journal of Psychiatry and Neurological Sciences 2011;24:113-20.  Back to cited text no. 22
Uyar HN, Vural AP, Kocael Ö, Köle İH, Dağdelen F, Kırtıl İY. Evaluation of Complaints, Diagnoses, and Drug Usage Characteristic in An Outpatient Clinic of Child and Adolescent Psychiatry. Journal of Uludağ Universty Medical Faculty 2014;40:75-83.  Back to cited text no. 23
Blomqvist M, Augustsson M, Bertlin C, Holmberg K, Fernell E, Dahllöf G, et al. How do children with attention deficit hyperactivity disorder interact in a clinical dental examination? A video analysis. Eur J Oral Sci 2005;113:203-9.  Back to cited text no. 24
Blomqvist M, Holmberg K, Fernell E, Dahllöf G. A retrospective study of dental behavior management problems in children with attention and learning problems. Eur J Oral Sci 2004;112:406-11.  Back to cited text no. 25
Blomqvist M, Holmberg K, Fernell E, Ek U, Dahllöf G. Oral health, dental anxiety, and behavior management problems in children with attention deficit hyperactivity disorder. Eur J Oral Sci 2006;114:385-90.  Back to cited text no. 26
Clavenna A, Bonati M. Safety of medicines used for ADHD in children: A review of published prospective clinical trials. Arch Dis Child 2014;99:866-72.  Back to cited text no. 27
Pataki CS, Carlson GA, Kelly KL, Rapport MD, Biancaniello TM. Side effects of methylphenidate and desipramine alone and in combination in children. J Am Acad Child Adolesc Psychiatry 1993;32:1065-72.  Back to cited text no. 28
Tenovuo J. Antimicrobial function of human saliva – How important is it for oral health? Acta Odontol Scand 1998;56:250-6.  Back to cited text no. 29
Chau YC, Peng SM, McGrath CP, Yiu CK. Oral health of children with attention deficit hyperactivity disorder: Systematic review and meta-analysis. J Atten Disord 2017:1087054717743331.  Back to cited text no. 30
Medori R, Ramos-Quiroga JA, Casas M, Kooij JJ, Niemelä A, Trott GE, et al. A randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry 2008;63:981-9.  Back to cited text no. 31
Mazengo MC, Tenovuo J, Hausen H. Dental caries in relation to diet, saliva and cariogenic microorganisms in Tanzanians of selected age groups. Community Dent Oral Epidemiol 1996;24:169-74.  Back to cited text no. 32
Leone CW, Oppenheim FG. Physical and chemical aspects of saliva as indicators of risk for dental caries in humans. J Dent Educ 2001;65:1054-62.  Back to cited text no. 33
Moreno EC, Varughese K, Hay DI. Effect of human salivary proteins on the precipitation kinetics of calcium phosphate. Calcif Tissue Int 1979;28:7-16.  Back to cited text no. 34
Orstavik D, Kraus FW. The acquired pellicle: Immunofluorescent demonstration of specific proteins. J Oral Pathol 1973;2:68-76.  Back to cited text no. 35
Scannapieco FA, Torres GI, Levine MJ. Salivary amylase promotes adhesion of oral streptococci to hydroxyapatite. J Dent Res 1995;74:1360-6.  Back to cited text no. 36
Rohleder N, Wolf JM, Maldonado EF, Kirschbaum C. The psychosocial stress-induced increase in salivary alpha-amylase is independent of saliva flow rate. Psychophysiology 2006;43:645-52.  Back to cited text no. 37
Tukia-Kulmala H, Tenovuo J. Intra- and inter-individual variation in salivary flow rate, buffer effect, lactobacilli, and mutans streptococci among 11- to 12-year-old schoolchildren. Acta Odontol Scand 1993;51:31-7.  Back to cited text no. 38
Behr M, Hahnel S, Faltermeier A, Bürgers R, Kolbeck C, Handel G, et al. The two main theories on dental bruxism. Ann Anat 2012;194:216-9.  Back to cited text no. 39
Winocur E, Gavish A, Voikovitch M, Emodi-Perlman A, Eli I. Drugs and bruxism: A critical review. J Orofac Pain 2003;17:99-111.  Back to cited text no. 40
Su Y, Sinko PJ. Drug delivery across the blood-brain barrier: Why is it difficult? How to measure and improve it? Expert Opin Drug Deliv 2006;3:419-35.  Back to cited text no. 41
Bimstein E, Wilson J, Guelmann M, Primosch R. Oral characteristics of children with attention-deficit hyperactivity disorder. Spec Care Dentist 2008;28:107-10.  Back to cited text no. 42
Malki GA, Zawawi KH, Melis M, Hughes CV. Prevalence of bruxism in children receiving treatment for attention deficit hyperactivity disorder: A pilot study. J Clin Pediatr Dent 2004;29:63-7.  Back to cited text no. 43
Mendhekar DN, Andrade C. Bruxism arising during monotherapy with methylphenidate. J Child Adolesc Psychopharmacol 2008;18:537-8.  Back to cited text no. 44
Mota-Veloso I, Celeste RK, Fonseca CP, Soares ME, Marques LS, Ramos-Jorge ML, et al. Effects of attention deficit hyperactivity disorder signs and socio-economic status on sleep bruxism and tooth wear among schoolchildren: Structural equation modelling approach. Int J Paediatr Dent 2017;27:523-31.  Back to cited text no. 45
Gilbert GH, Heft MW, Duncan RP. Mouth dryness as reported by older floridians. Community Dent Oral Epidemiol 1993;21:390-7.  Back to cited text no. 46
Rosenberg SS, Kumar S, Williams NJ. Attention deficit/hyperactivity disorder medication and dental caries in children. J Dent Hyg 2014;88:342-7.  Back to cited text no. 47
Schultz ST, Shenkin JD, Horowitz AM. Parental perceptions of unmet dental need and cost barriers to care for developmentally disabled children. Pediatr Dent 2001;23:321-5.  Back to cited text no. 48


  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Materials and Me...
    Article Tables

 Article Access Statistics
    PDF Downloaded315    
    Comments [Add]    

Recommend this journal