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ORIGINAL ARTICLE
Year : 2019  |  Volume : 22  |  Issue : 12  |  Page : 1752-1757

Oral mucosal melanoma in four Nigerian teaching hospitals


1 Oral Pathology Unit, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Nigeria, Ile-Ife, Nigeria
2 Department of Oral and Maxillofacial Pathology/ Biology, Faculty of Dental Sciences, College of Medicine, University of Lagos, Ile-Ife, Nigeria
3 Department of Oral Pathology, Faculty of Dentistry, University of Ibadan, Ile-Ife, Nigeria
4 Department of Oral Maxillofacial Surgery and Oral Pathology, Faculty of Dentistry, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
5 Oral Pathology Unit, Department of Oral and Maxillofacial Surgery, Clinical Dental Services, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria

Correspondence Address:
Dr. M C Nwoga
Oral Pathology Unit, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Nigeria
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njcp.njcp_176_19

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Background: Oral mucosal melanoma (OMM) is a malignant lesion of melanocytes of oral epithelium. The prevalence in four Nigerian teaching hospitals is reported. Aims: This study shows the hospital based prevalence and the clinicopathologic features of OMM in four Nigerian teaching hospitals. Subjects and Methods: A retrospective study of patients diagnosed with OMM in four teaching hospitals in Nigeria was carried out. All records of patients with orofacial lesions from 1969 to 2016 were identified and retrieved from the archives of four oral pathology departments. The biodata and relevant clinicopathologic information of those diagnosed with OMM were reviewed. Data analysis was done with SPSS for Windows, version 20. Results: There were 10,877 orofacial lesions managed during the period. Oral malignant lesions constituted 14.4% (1,552/10,877). OMM was diagnosed in ten patients with prevalences of 0.09% and 0.6% of all orofacial lesions and oral malignancies, respectively. There was a male predilection of 4:1 and a mean age of occurrence of 53.8 (±12.6) years. The palate was the most frequent site, 40.0% (4/10). Regional lymph nodes were hard, fixed, or matted in 50.0% (5/10) of patients and distant metastases observed in 20.0% (2/10). Among those followed up, only one was documented alive after 6 months. Amelanotic OMM, 20.0% (2/10) did not show ulceration or regional and distant metastasis. Conclusions: OMM has a low prevalence but with poor prognosis. Amelanotic OMM showed less clinical aggression. Early diagnosis and prompt treatment are recommended.


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