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Year : 2019  |  Volume : 22  |  Issue : 2  |  Page : 149-153

Association between IL-10 polymorphisms rs1800896 and rs1800871 and risk of acute pancreatitis in Chinese Han population: An update systemic review and meta-analysis

Department of Surgery, The Second Affiliated Hospital of Zhejiang University, Hangzhou, P.R. China

Correspondence Address:
Dr. Y Zhu
Department of Surgery, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou
P.R. China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njcp.njcp_57_18

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The association between interleukin-10 (IL-10) promoter region (1082 A/G (rs1800896), 819 C/T (rs1800871)) polymorphisms, and acute pancreatitis (AP) is inconclusive in Chinese Han population. In this study, six eligible studies extracted from the databases of PubMed, Web of Science, and Cochrane Library were evaluated. The results revealed a significant association between 1082 A/G (rs1800896) polymorphism and AP risk in all these five models (AG/AA: OR = 1.19, 95% Cl = 1.02–1.40, P = 0.03; GG/AA: OR = 1.80, 95% Cl = 1.38–2.23, P = 0.01; AG+GG/AA: OR = 1.29, 95% Cl = 1.11–1.50, P = 0.01; GG/AG+AA: OR = 1.62, 95% Cl = 1.27–2.08, P = 0.01; G/A: OR = 1.29, 95% Cl = 1.15–1.45, P = 0.01). In contrast, no statistically significant association was found in all these five models for 819 C/T (rs1800871) polymorphism. In summary, IL-10 polymorphism 1082 A/G (rs1800896) could increase the risk of AP in Chinese Han population.

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