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Year : 2019  |  Volume : 22  |  Issue : 2  |  Page : 201-207

Study of association between sickle cell trait and renal dysfunction among young adults in South-west Nigeria

1 Department of Medicine, University of Medical Sciences Teaching Hospital, Ondo, Nigeria
2 Department of Medical Laboratory Services, University of Medical Sciences Teaching Hospital, Ondo, Nigeria
3 Renal Unit, Obafemi Awolowo University Teaching Hospital, Ile Ife, Nigeria
4 Department of Haematology, University of Medical Sciences Teaching Hospital, Ondo, Nigeria
5 Department of Dietetics, University of Medical Sciences Teaching Hospital, Ondo, Nigeria
6 Department of Nursing Science, University of Medical Sciences Teaching Hospital, Ondo, Nigeria

Correspondence Address:
Dr. A A Akinbodewa
PMB 542, Medical Village, 23434 Ondo Township, Ondo State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njcp.njcp_253_18

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Background: Although sickle cell disease has become a recognized etiology of chronic kidney disease (CKD), the sickle cell trait (SCT) variant was until recently believed to be a benign carrier state with little or no effect on the health of affected individuals. However, recent studies now appear to suggest an association between SCT and CKD. Objective: The objective of the study is to determine the association between SCT (hemoglobin AS) and renal dysfunction among young Nigerian adults. Methodology: This was a cross-sectional, descriptive study among apparently healthy undergraduates of Adeyemi College of Education, Ondo, southwest Nigeria. Their hemoglobin genotypes were determined using standard alkaline electrophoresis; their blood pressure, anthropometry, serum total cholesterol (TC), creatinine, and estimated glomerular filtration rate (eGFR) were determined. Data analyzed using Statistical Package for Social Sciences (SPSS) 20 were significant at P < 0.05. Results: Six hundred and two subjects with HbAS (SCT, n = 465) and HbAA (non-SCT, n = 137) were studied. Their age range was 18–30 years with male-to-female ratio 1:3.8. There was no difference in the prevalence of renal dysfunction between SCT and non-SCT subjects (5.1% vs. 5.2%, P = 0.591). There was no increased risk of CKD among subjects with SCT (PR, 0.99 at 95% CI [0.417–2.348]). Conclusion: SCT was not associated with increased risk of renal dysfunction among young adults in Nigeria. Further studies are needed to clarify the controversy, especially in Nigeria, with a relatively higher prevalence of SCT.

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