Medical and Dental Consultantsí Association of Nigeria
Home - About us - Editorial board - Search - Ahead of print - Current issue - Archives - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 1950   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Year : 2019  |  Volume : 22  |  Issue : 5  |  Page : 727-730

Plateletcrit: A possible biomarker of inflammation in hepatitis A infection

1 Department of Paediatrics, University of Gaziantep, Gaziantep, Turkey
2 Department of Paediatric Haemotology, University of Gaziantep, Gaziantep, Turkey
3 Department of Paediatric Gastroenterology, Hepatology and Nutrition, Ankara Yıldırım Beyazıt University, Ankara, Turkey

Correspondence Address:
Assist. Prof. M E Coskun
Department of Paediatrics, University of Gaziantep, Gaziantep
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njcp.njcp_331_18

Rights and Permissions

Objectives: Hepatitis A (HepA) virus is a common infection worldwide that causes inflammation of the liver. Platelet index, particularly plateletcrit (PCT) which shows percentage of blood occupied by platelets, is thought to be potential marker of inflammation. Therefore, we aimed to investigate the changes in PCT percentages during HepA infection. Subjects and Methods: Seventy-three children with a diagnosis of acute HepA infection and 68 age- and sex-matched healthy controls were enrolled in this study. Their values of platelet indices [PCT and mean platelet volume (MPV)] obtained from complete blood counts, which were analyzed by XN-1000 analyzer, were statistically compared with each other. Results: PCT and MPV of the patients were found to be higher than those of controls (8.89 ± 1.30 vs 8.03 ± 0.89 for MPV and 0.29 ± 0.11 vs 0.24 ± 0.05 for PCT; P = 0.000, P = 0.002, respectively). In addition, PCT and platelet counts showed a significant negative correlation with alanine aminotransferase (ALT) levels, which indirectly represents inflammation in the liver (PCT: r = −0.368, P = 0.002; platelet count: r = −0.304, P = 0.009). In contrast, MPV levels were not found to demonstrate any correlation with ALT (r = −0.205, P = 0.082). Conclusion: Both MPV and PCT are capable of reflecting the inflammation during acute HepA inflammation. Also, PCT shows a significant negative correlation with the degree of inflammation.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded60    
    Comments [Add]    

Recommend this journal