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ORIGINAL ARTICLE
Year : 2020  |  Volume : 23  |  Issue : 6  |  Page : 870-878

Impact of diabetes mellitus on sexuality in a developing country setting: A case-control study in Calabar, Nigeria


1 Department of Family Medicine, University of Calabar Teaching Hospital, Calabar, Nigeria
2 Department of Community Medicine, University of Calabar Teaching Hospital, Calabar, Nigeria
3 Department of Internal Medicine, University of Calabar Teaching Hospital, Calabar, Nigeria

Date of Submission07-Jan-2020
Date of Acceptance07-Apr-2020
Date of Web Publication11-Jun-2020

Correspondence Address:
Dr. O E Omoronyia
Department of Community Medicine, University of Calabar, Calabar
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njcp.njcp_5_20

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   Abstract 


Background: This study aimed to identify the unmet sexual health needs of the patients with diabetes seen in a tertiary healthcare facility in Nigeria. Methods: Case-control study design and random sampling method were utilized to recruit type 2 diabetic cases from the University of Calabar Teaching Hospital (UCTH), Calabar, Nigeria. Female Sexual Function Index (FSFI) and International Index for Erectile Function (IIEF) were used to assess sexual function. Result: There were 330 subjects with the mean age of 54.9 years. Among females, the FSFI score was lower among cases compared with controls (18.8 vs. 23.1, P < 0.05). Except for sexual interest, mean scores for all other domains of sexual function were also lower among cases (P < 0.05). Among males, there was no significant difference in overall mean IIEF score comparing cases and controls (40.0 vs. 41.7, P > 0.05). However, mean scores for desire and satisfaction was lower among cases compared with controls (P < 0.05). Older age, unmarried status, presence and duration of hypertension were associated with sexual dysfunction among females. The use of supplements was associated with sexual dysfunction among males (P < 0.05). Conclusion: Sexual dysfunction is common among diabetics with variation in affected domains in both genders in the study setting. These unmet sexual health needs focus to be addressed.

Keywords: Calabar, diabetes mellitus, erection, Nigeria, sexual function


How to cite this article:
Ayuk A E, Omoronyia O E, Asibong U E, Enang O E, Legogie A O, Nwafor K N. Impact of diabetes mellitus on sexuality in a developing country setting: A case-control study in Calabar, Nigeria. Niger J Clin Pract 2020;23:870-8

How to cite this URL:
Ayuk A E, Omoronyia O E, Asibong U E, Enang O E, Legogie A O, Nwafor K N. Impact of diabetes mellitus on sexuality in a developing country setting: A case-control study in Calabar, Nigeria. Niger J Clin Pract [serial online] 2020 [cited 2020 Jul 15];23:870-8. Available from: http://www.njcponline.com/text.asp?2020/23/6/870/286437




   Background Top


An estimated 425 million people globally have diabetes mellitus, which has remained a global public health problem without a definite cure.[1] In Africa, Nigeria has the highest number of people living with diabetes, with at least a twofold increase in its prevalence within the last two decades from 2.2% in 1997 to 5.8% in 2017.[2],[3] Among other debilitating consequences, the often undiagnosed chronic disease significantly contributes to the onset and progression of sexual dysfunction. In both sexes, type 2 diabetic patients seen in primary care settings, have been found to have a high prevalence of sexual dysfunction, with a preponderance of erectile dysfunction in men and low sexual desire and lack of lubrication in women.[4] Other potential predictors include longer duration of diabetes, presence of hypertension, poor glycemic control, older age, and obesity.[5] This potentially frustrating psychosexual complication has tangible and intangible cost implications for the patients and health systems.[6] For instance, independent studies of erectile dysfunction in the USA [7] and female sexual dysfunction in the UK [8] reported annual cost estimates of $15 billion and ≤53 million, respectively.

Consequently, there is growing research interest in sexual dysfunction among the patients with diabetes. This includes female sexual dysfunction (FSD) characterized by the presence of loss of libido, the problem with arousal, orgasm, lubrication, and pain before, during, and after sexual intercourse. Previous studies have reported a high prevalence of FSD among the women with diabetes [9] Older age, being unmarried, menopause, and depression have been significantly associated with the presence of FSD (P < 0.00).[10],[11],[12],[13] However, despite years of research interest in FSD among the women with diabetes, there is still scant literature in the subject area in the developing countries where female sexuality is rarely discussed freely. Even among the men with diabetes, the dynamics of sexual dysfunction has not been studied in the South-South region, which has one of the highest prevalence rates of diabetes and comorbid hypertension in Nigeria.[3]

Besides the paucity of literature on sexual dysfunction among the patients with diabetes in the study setting, there is a substantial limit to the interpretation of the few studies conducted in many developing countries.[14] Instruments used, do not usually provide a detailed assessment of the different components of sexual function. Also, assessment of predictors of sexual dysfunction is usually limited to sociodemographic characteristics, with the common exclusion of relevant clinical, laboratory, and health system factors. This study was therefore aimed at contributing to bridging current research gaps on sexual dysfunction among the patient with diabetes in a diverse multicultural developing country setting, where diabetes is a prevalent chronic disease. Finding will constitute the useful baseline for the region, as well as contribute to improvement in best practices for long-term management of sexual dysfunction among the vast majority of poor diabetics with little or no health insurance in the developing countries.[6],[8]


   Methods Top


The study design was case-control, with diabetic cases recruited from medical wards and out-patient clinics in UCTH Calabar, while age and sex-matched controls were non-diabetic normotensive civil servants and retirees. A systematic random sampling method was used to recruit both cases and controls. Ethical approval was obtained from the UCTH Research Ethics Committee before obtaining data from consenting adult subjects that were at least 18 years old. Subjects with type 1 diabetes and that were within 6 months of diagnosis of diabetes mellitus were excluded from the study. Also, those that had been sexually inactive for the last 6 months as well as those with a history of previous pelvic/perineal surgery such as prostatectomy, hemorrhoidectomy, and pelvic floor repairs were excluded. Subjects that were 75 years or older were also excluded from the study.

Validated and pretested Female Sexual Function Index (FSFI) and International Index for Erectile Function (IIEF) were used to assess sexual function for female and male subjects, respectively. The FSFI instrument comprised 0-5 Likert-scaled 19 items within six domains.[15] For each domain, individual items were summed up then multiplied by respective factors to obtain domain scores. Domain scores were summed to obtain total FSFI score ranging from 2 to 36, with the higher score indicating better degree of sexuality and vice versa.[15] Mean domain and total scores were compared between study groups using independent t-test. The 15-item IIEF instrument consist of 6, 2, 2, 3, and 2 Likert-scaled items in the erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction domains, respectively. Total score ranges from 5 to 75. Items are summed to obtain a domain and total scores, which are compared between study groups using independent t-test. The P value < 0.05 was considered statistically significant.


   Results Top


The response rate was 95.4%, and complete data were obtained from 330 subjects comprising an equal proportion of diabetic cases and age/sex-matched normotensive non-diabetic controls. Male: female was 1:0.9 and the mean age was 54.9 ± 9.6 years ranging from 36 to 74 years. Approximately two-thirds (66.0%) of subjects were within 51-70 years old [Table 1]. Most subjects were married (80.9%), had at least a secondary level of education (88.8%), and never smoked (72.4%). Roman Catholic (41.2%) was the commonest religion. Compared with controls, cases had a significantly higher proportion of being widowed, having a lower level of education, previous smoking history, and consuming alcohol occasionally (P = 0.00, [Table 1]). Mean Body Mass Index (BMI) was 26.7 ± 4.7, ranging from 18.8 to 41.5 kg/m2. Most subjects (61.2%) were either overweight or obese [Table 2]. Compared with controls, significantly higher proportion of cases were overweight and obese (P = 0.00). A total of 141 subjects (42.7%) were hypertensive, with mean duration of hypertension being 8.5 ± 3.6 years, ranging from 1 to 15 years. Mean systolic, diastolic, and mean arterial blood pressures were 131.7 ± 15.9, 81.4 ± 10.6, and 98.2 ± 11.6 mmHg, respectively.
Table 1: Sociodemographic characteristics of subjects (n=330)

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Table 2: Anthropometric and clinical characteristics of subjects (n=330)

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Approximately a quarter (25.8%) and a third (34.2%) reported having sexual problems and being asked about their sexual life by their medical doctor, respectively. Admitting the presence of sexual problems and being asked about sexual life was proportionally commoner among cases compared with controls (P < 0.05). Fifty one subjects (15.5%) used supplements to enhance their sexual life, but there was no significant difference in proportion comparing cases and controls (P > 0.05, [Table 2]).

[Table 3] compares mean scores of FSFI between female cases and controls for each item and domain of the female sexual function. Except for sexual desire and arousal, mean sum scores for all other domains of sexual function were significantly lower among cases compared with controls (P < 0.05). Overall FSFI score was also significantly lower among cases compared with controls (P = 0.00). [Table 4] compares mean scores of IIEF between male cases and controls for each item and domain of the male sexual function. Mean scores for satisfaction were significantly lower among cases compared with controls. Each item, as well as mean sum score for erection, orgasm, desire, intercourse, and overall satisfaction were lower among cases compared with controls, but statistical significance was found only for desire and overall satisfaction scores (P < 0.05). There was no significant difference in overall mean total IIEF score comparing cases and controls (P > 0.05).
Table 3: Comparison of each component of FSFI scores among female subjects (n=156)

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Table 4: Comparison of each component of IIEF scores among male subjects (n=174)

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[Table 5] assesses the relationship between sociodemographic characteristics and sexual function score among female (FSFI) and male (IIEF) cases. Among females, mean scores were significantly lower for those that were older than 50 years, unmarried, and reported having sexual problems (P = 0.00). Other characteristics including the level of education, religion, consumption of alcohol, and use of supplements, were not significantly associated with the FSFI (P > 0.05). Among males, mean scores were lower among those that were older than 50 years, unmarried, had primary or less level of education, but these differences were not statistically significant (P > 0.05). Less frequent consumption of alcohol, admitting having sexual problems, and never being asked about sexual life by a doctor, were significantly associated with lower sexual function scores (P < 0.05). The use of supplement was associated with a lower mean score, though this difference was marginally significant (P = 0.05).
Table 5: Relationship between sociodemographic characteristics and sexual function score for cases (n=165)

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[Table 6] assesses the relationship between clinical and laboratory parameters and sexual function scores among female (FSFI) and male (IIEF) cases. Significantly lower sexual function scores were obtained for cases with comorbid hypertension, but statistical significance was found only among females (P < 0.05). Among females, the BMI, duration of diabetes, duration of hypertension, levels of systemic blood pressure, HbA1c, total cholesterol, and LDL cholesterol were indirectly correlated with the FSFI scores, but statistical significance was found only for the duration of diabetes, hypertension, and blood pressure. Among males, only (BMI) and duration of hypertension were significantly indirectly correlated with the IIEF score (P < 0.00).
Table 6: Relationship between clinical parameters and sexual function score among cases (n=165)

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   Discussion Top


This study was aimed at comparing the sexual function of the patients with diabetes and their age/sex-matched controls. The women with diabetes compared with non-diabetic controls had significantly lower levels of sexual function in all domains except desire and arousal [Table 3]. This finding is in tune with a report from a similar study in Egypt,[16] Iran,[11] Turkey,[17] China,[18] and Southeast Nigeria,[12] where the women with diabetes compared with controls had significantly lower levels of sexual function in all domains (P < 0.05). Diabetes-mediated alteration in vascularization network, lamina propria, and expression of androgen receptors in the vagina may account for significantly lower levels of lubrication, orgasm, and pain domains of sexual function.[19] Sexual desire and arousal may be more dependent on the psychological state of individuals, enabling environmental ambience, partner relationship, and skills for initiating sex. However, a similar study in Malaysia [20] and Boston, MA, USA [21] found no significant difference in orgasmic function comparing diabetic and non-diabetic women. Sociocultural difference, especially in individual and societal perception towards female sexuality, may account for these findings.[22]

Among men in this study, there was no significant difference in the level of sexual function comparing cases and controls for all domains except sexual desire [Table 4]. This finding is at variance with reports from the systematic review where most studies found a significantly lower level of sexual function among diabetic compared with non-diabetic subjects.[14] Ethnic difference in perception towards human sexuality may account for these findings.[23] Diabetes-mediated erectile dysfunction is thought to be caused by endothelial dysfunction and damage to smooth muscle tissues of corpus carvenosa.[24] Significantly lower levels of sexual desire among cases compared with controls may be associated with depressive states commonly found among the patients with diabetes.[25] Though desire is usually the initial stage of sexual activities, cases in this study were not found to be significantly affected by succeeding stages assessed within the erectile function, orgasm, intercourse, and overall satisfaction domains. Counseling with an emphasis on improved partner relationship and skills may be a key to restore sexual desire among the patients with diabetes. in the study setting. Low daily dose of 5 mg taladafil has also been found to effectively improve sexual function among the men with diabetes.[26]

The older and unmarried cases compared with controls in this study, had lower sexual function scores, though statistical significance was found only for females [Table 5]. The effect of increasing age on sexual function among diabetics has been reported in several studies.[27] Aging is thought to be associated with changes in estrogen and vaginal dryness in women, as well as testosterone and neurovascular perfusion of erectile tissues in men, which may worsen sexual function among diabetics.[28] Improved physical exercise, psychotherapy, use of vaginal creams, supplements, and phosphodiesterase inhibitors are the various remedies used with varying degrees of long-term success.[27],[29] Owing to sociocultural peculiarities of the study setting, unmarried status especially among older adult diabetics, may influence the frequency and/or regularity of sexual activity. This finding suggests that the potential benefit of healthy partner relationship in reducing the psychological impact of diabetes on sexual functioning may be missed by unmarried cases.[30] Also, compared with non-menopausal women, lower FSFI scores among menopausal subjects, suggests significant adverse effects of estrogen deficiency on sexual function in the study setting. The effect of estrogen deficiency may, however, be modified by several factors, including quality of partner relationship, as well as knowledge and access to preventive maternal health care.[31] Findings from a review of studies on menopause suggest better sexual function among women in developed compare with developing countries. This difference may be due to better knowledge and access to maternal healthcare among women in developed countries.[31]

Subject's admission to having problems with sexual life in this study was significantly associated with lower sexual function for both males and females [Table 5]. This finding has implications for improved clinical practice and counseling. For instance, it suggests that simple inquiry of client's challenges with sex may be a potentially sensitive and specific tool for the overall assessment of their sexuality. Unfortunately, such key discussion is rarely initiated in most clinic sessions,[32] as also indicated in this study where two-thirds (65.8%) of subjects were never asked about their sexual life [Table 2]. Owing to busy diabetic clinic sessions in many resource-limited settings, healthcare providers may be tempted to prioritize glycemic control and clinical management over the sexual wellbeing of their patients.[33] However, such negligence of duty by healthcare providers may be contributing significantly to the high burden of sexual dysfunction, and potential depression and low quality of life among the patients with diabetes in developing country settings.[33]

Among male cases, the use of supplements for enhancement of sexuality was found to be marginally associated with reduced sexual function. This paradoxical association suggests the inefficacy of locally available supplements, which may not be addressing the multifactorial etiologic basis for sexual dysfunction among the men with diabetes.[28] Tachyphylaxis accruing from long-term non-prescription use, and high prevalence of patronage of fake/adulterated medications in Nigeria, may account for inefficacy of supplements found in this study.[34] Unfortunately, this study is limited by non-assessment of specific supplements used by each subject, for better evaluation of rationale for their apparent inefficacies. Also, subjects may be having product marketing-based undue high expectations of efficacy of supplements, leading to an equally high degree of disappointment when they fail.[34] Consequently, use of supplements for enhancement of sexual function may be causing more harm than good for the patients with diabetes in the study setting.

In this study, the presence and duration of hypertension and diabetes had a significant adverse impact on sexuality among females. Among males, only the duration of hypertension had a significant adverse impact on their sexuality [Table 6]. Development of complications over time, and potentially increasing pill burden leading to depression, may be contributing to impairment of sexuality among the patients with diabetes.[35] Also, BMI was indirectly correlated with sexual function, but statistical significance was found only among males. Obesity has been reported to be associated with erectile dysfunction, based on endothelial dysfunction, potentially impairing perfusion of erectile tissue, and reduction in testosterone levels.[36] Despite these findings, this study is limited by a lack of assessment of other potential causes of sexual dysfunction, including the previous history of sexual abuse, partner relationship [37] and other forms of comorbid medical conditions.[38] Also, the IIEF instrument used for assessment of ED in men is limited by the inability to ascertain organic etiology which may require penile duplex Doppler ultrasonography which was not done.[39] This may have caused overrepresentation of ED, especially if a significant proportion had had psychogenic rather than organic forms of the disease. Nevertheless, these findings provide a useful baseline of a pattern of sexual dysfunction among the patients with diabetes in a developing country region with a high burden of diabetes and hypertension.[3]


   Conclusion Top


This study found a high degree of sexual dysfunction among diabetic compared with the non-diabetic patients, especially among women in the study setting. An effective multi-disciplinary team comprising diabetologist, urologist, gynecologist, and psychiatrist is required to address this challenge of the impact of diabetes on sexual function of patients. During each clinic consultation, healthcare providers should endeavor to privately enquire about their client's sexual life, with recognition of domains of sexual function that may be affected towards the provision of more effective diabetes care services in developing countries. More comprehensive clinical clerkship should be done for the identification of potential multifactorial risk factors for sexual dysfunction among diabetic and non-diabetic adults. Spouses of patients may also be involved in counseling sessions for the best clinical outcome.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
IDF, Diabetes atlas, in International Diabetes Federation. 2017, 8th Edition: Brussels.  Back to cited text no. 1
    
2.
Akinkugbe O. Non-Communicable Diseases in Nigeria: National Survey (Final Report) on Hypertension, Coronary Heart Disease, Diabetes Mellitus, Haemoglobinopathies, G6PD deficiency and Anaemia. National Expert Committee on Non-Communicable Disease, Lagos, Nigeria, 1997. Federal Ministry of Health and Social Services.  Back to cited text no. 2
    
3.
Uloko AE, Musa BM, Ramalan MA, Gezawa ID, Puepet FH, Uloko AT, et al. Prevalence and risk factors for diabetes mellitus in Nigeria: A systematic review and meta-analysis. Diabetes Ther 2018;9:1307-16.  Back to cited text no. 3
    
4.
Bijlsma-Rutte A, Braamse AMJ, van Oppen P, Snoek FJ, Enzlin P, Leusink P, et al. Screening for sexual dissatisfaction among people with type 2 diabetes in primary care. J Diabetes Complications 2017;31:1614-9.  Back to cited text no. 4
    
5.
Enzlin P, Mathieu C, Van den Bruel A, Bosteels J, Vanderschueren D, Demyttenaere K. Sexual dysfunction in women with type 1 diabetes: A controlled study. Diabetes Care 2002;25:672-7.  Back to cited text no. 5
    
6.
Asmelash D, Asmelash Y. The burden of undiagnosed diabetes mellitus in adult African population: A systematic review and meta-analysis. J Diabetes Res 2019;5:6-11.  Back to cited text no. 6
    
7.
Wessells H, Joyce GF, Wise M, Wilt TJ. Erectile dysfunction. J Urol 2007;177:1675-81.  Back to cited text no. 7
    
8.
Balon R, Burden of sexual dysfunction. J Sex Marital Ther 2017;43:49-55.  Back to cited text no. 8
    
9.
Rahmanian E, Salari N, Mohammadi M, Jalali R. Evaluation of sexual dysfunction and female sexual dysfunction indicators in women with type 2 diabetes: A systematic review and meta-analysis. Diabetol Metab Syndr 2019;11:73.  Back to cited text no. 9
    
10.
Enzlin P, Rosen R, Wiegel M, Brown J, Wessells H, Gatcomb P, et al. Sexual dysfunction in women with type 1 diabetes: Long-term findings from the DCCT/EDIC study cohort. Diabetes Care 2009;32:780-5.  Back to cited text no. 10
    
11.
Alizadeh NS, Arasteh M, Mohsenpour B, Karimian F, Alizadeh NS. Comparison of sexual dysfunction between diabetic and non-diabetic women. J Midlife Health 2013;4:167-71.  Back to cited text no. 11
    
12.
Ezeani I, Onyeonoro U, Ugwu E. Evaluation of female sexual function in persons with type 2 diabetes mellitus seen in a tertiary hospital in Southeast Nigeria with emphasis on its frequency and predictors. J Sex Marital Ther 2019:1-7.  Back to cited text no. 12
    
13.
Fatemi SS, Taghavi SM, Evaluation of sexual function in women with type 2 diabetes mellitus. Diab Vasc Dis Res 2009;6:38-9.  Back to cited text no. 13
    
14.
Kouidrat Y, Pizzol D, Cosco T, Thompson T, Carnaghi M, Bertoldo A, et al. High prevalence of erectile dysfunction in diabetes: A systematic review and meta-analysis of 145 studies. Diabet Med 2017;34:1185-92.  Back to cited text no. 14
    
15.
Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The female sexual function index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000;26:191-208.  Back to cited text no. 15
    
16.
Ahmed MR, Shaaban MM, Sedik WF, Mohamed TY. Prevalence and differences between type 1 and type 2 diabetes mellitus regarding female sexual dysfunction: A cross-sectional Egyptian study. J Psychosom Obstet Gynaecol 2018;39:176-81.  Back to cited text no. 16
    
17.
Duman NB. Frequency of sexual dysfunction and its causative factors among diabetic women in Turkey. Pak J Med Sci 2014;30:558-63.  Back to cited text no. 17
    
18.
Li F, Wang Y, Xiao L, Lou Q, Fish AF. Frequency, severity, and risk factors related to sexual dysfunction in Chinese women with T2D. J Diabetes 2016;8:544-51.  Back to cited text no. 18
    
19.
Baldassarre M, Alvisi S, Berra M, Martelli V, Farina A, Righi A, et al. Changes in vaginal physiology of menopausal women with type 2 diabetes. J Sex Med 2015;12:1346-55.  Back to cited text no. 19
    
20.
Ismail AH, Baw R, Sidi H, Guan NC, Midin M, Nik Jaafar NR, et al. Orgasmic dysfunction among Malay diabetic women in Malaysia. Compr Psychiatry 2014;55(Suppl 1):S29-33.  Back to cited text no. 20
    
21.
Wallner LP, Sarma AV, Kim C. Sexual functioning among women with and without diabetes in the Boston Area Community Health Study. J Sex Med 2010;7:881-7.  Back to cited text no. 21
    
22.
Kaya-Erten Z, Zincir H, Ozkan F, Selçuk A, Elmali F. Sexual lives of women with diabetes mellitus (type 2) and impact of culture on solution for problems related to sexual life. J Clin Nurs 2014;23:995-1004.  Back to cited text no. 22
    
23.
Taloyan M, Wajngot A, Johansson SE, Tovi J, Sundquist J. Ethnic differences in dissatisfaction with sexual life in patients with type 2 diabetes in a Swedish town. BMC Public Health 2010;10:536.  Back to cited text no. 23
    
24.
Huang SY, Chen S, Feng YP. [Advances in diabetic erectile dysfunction]. Zhonghua Nan Ke Xue 2006;12:178-80, 182.  Back to cited text no. 24
    
25.
Rosen RC, Seidman SN, Menza MA, Shabsigh R, Roose SP, Tseng LJ, et al. Quality of life, mood, and sexual function: A path analytic model of treatment effects in men with erectile dysfunction and depressive symptoms. Int J Impot Res 2004;16:334-42.  Back to cited text no. 25
    
26.
Bolat M, Cinar O, Akdeniz E, Aşcı R. Low dose daily versus on-demand high dose tadalafil in diabetic patients with erectile and ejaculatory dysfunction. Int J Impot Res 2018;30:102-7.  Back to cited text no. 26
    
27.
Adeniyi A, Adeleye J, Adeniyi C. Diabetes, sexual dysfunction and therapeutic exercise: A 20 year review. Curr Diabetes Rev 2010;6:201-6.  Back to cited text no. 27
    
28.
Corona G, Giorda CB, Cucinotta D, Guida P, Nada E; SUBITO-DE Study Group. Sexual dysfunction in type 2 diabetes at diagnosis: Progression over time and drug and non-drug correlated factors. PLoS One 2016;11:e0157915.  Back to cited text no. 28
    
29.
Qureshi S, Ara Z, Qureshi VF, Al-Rejaie SS, Aleisa AM, Bakheet SA, et al. Sexual dysfunction in women: An overview of psychological/psychosocial, pathophysiological, etiological aspects and treatment strategies. Pharmacogn Rev 2007;1:41-8.  Back to cited text no. 29
    
30.
Galinsky A, Waite L. Sexual activity and psychological health as mediators of the relationship between physical health and marital quality. J Gerontol B Psychol Sci Soc Sci 2014;69:482-92.  Back to cited text no. 30
    
31.
Nazarpour S, Simbar M, Tehrani FR. Factors affecting sexual function in menopause: A review article. Taiwan J Obstet Gynecol 55:480-7.  Back to cited text no. 31
    
32.
Rakovac-Tisdall A, King TFJ, Mahmood WAW, Keat CS, Ali R, Abdin R, et al. Erectile dysfunction: They don't talk, we don't ask. Diabet Med 2018;35:667-8.  Back to cited text no. 32
    
33.
Manne-Goehler J, Atun R, Stokes A, Goehler A, Houinato D, Houehanou C, et al. Diabetes diagnosis and care in sub-Saharan Africa: Pooled analysis of individual data from 12 countries. Lancet Diabetes Endocrinol 2016;4:903-12.  Back to cited text no. 33
    
34.
Amadi L, Amadi M. Sustainable drug consumption, regulatory dynamics and fake drug repositioning in Nigeria: A case of NAFDAC. Sci-Afric J Sci Issues Res Essays 2014;2:412-9.  Back to cited text no. 34
    
35.
Lewis RW, Fugl-Meyer KS, Corona G, Hayes RD, Laumann EO, Moreira ED Jr, et al. Definitions/epidemiology/risk factors for sexual dysfunction. J Sex Med 2010;7:1598-607.  Back to cited text no. 35
    
36.
Diaz-Arjonilla M, Schwarcz M, Swerdloff RS, Wang C. Obesity, low testosterone levels and erectile dysfunction. Int J Impot Res 2009;21:89-98.  Back to cited text no. 36
    
37.
Shadman Z, Akhoundan M, Poorsoltan N, Larijani B, Arzaghi SM, Khoshniat M. Factors associated with sexual function in Iranian women with type 2 diabetes mellitus: Partner relationship as the most important predictor. Iran Red Crescent Med J 2014;16:e14941.  Back to cited text no. 37
    
38.
Chung SD, Chen YK, Kang JH, Keller JJ, Huang CC, Lin HC. Population-based estimates of medical comorbidities in erectile dysfunction in a Taiwanese population. J Sex Med 2011;8:3316-24.  Back to cited text no. 38
    
39.
Deveci S, O'Brien K, Ahmed A, Parker M, Guhring P, Mulhall JP. Can the International Index of Erectile Function distinguish between organic and psychogenic erectile function? BJU Int 2008;102:354-6.  Back to cited text no. 39
    



 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6]



 

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