Nigerian Journal of Clinical Practice

ORIGINAL ARTICLE
Year
: 2008  |  Volume : 11  |  Issue : 4  |  Page : 312--315

Effect of highly active antiretroviral therapy on CD4 count and weight in AIDS patients seen at the UITH, Ilorin


HO Olawumi, PO Olatunji, AK Salami, L Odeigah, JO Iseniyi 
 Department of Haematology & Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, Nigeria

Correspondence Address:
H O Olawumi
Department of Haematology & Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, Nigeria

OBJECTIVE: To determine the response on treatment-naïve HIV/AIDS patients to the Highly Active Antiretroviral Therapy (HAART) in terms of CD4 Count and Weight gain over a period of 2 1/2 years. METHODS: Patients with Acquired Immunodeficiency Syndrome (AIDS) were recruited under the Federal Government Highly Active Antiretroviral Therapy (HAART) programme at the University of Ilorin Teaching Hospital. The treatment regimen included Lamivudine, Starvudine and Nevirapine. The patients«SQ» responses were evaluated with respect to CD4 count and weight over the period of treatment. The diagnosis of HIV/AIDS was made on the basis of reactivity with two different ELISA reagents, and CD4 count was done with Dynal T4 Quant method. The weights (kg.) of the patients were taken at monthly visit. RESULTS: The duration of treatment for the patients analysed ranged from 1 month to 14 months. Analysis of CD4 count was possible in 105 patients. The mean post treatment CD4 count and weight were significantly higher than the pre-treatment values (p < 0.001 and p < 1.01) respectively. There were significant positive correlations (p < 0.05 and p < 0.001) between increases in CD4 count and weight respectively, and duration of treatment. In eight (8) patients, CD4 Count reduced or remained the same in spite of treatment. CONCLUSION: The HAART regime is associated with increase in CD4 Count and weight gain. While increases in CD4 Count and weight correlated with duration of therapy, there was no correlation between CD4 Count increase and weight gain.


How to cite this article:
Olawumi H O, Olatunji P O, Salami A K, Odeigah L, Iseniyi J O. Effect of highly active antiretroviral therapy on CD4 count and weight in AIDS patients seen at the UITH, Ilorin.Niger J Clin Pract 2008;11:312-315


How to cite this URL:
Olawumi H O, Olatunji P O, Salami A K, Odeigah L, Iseniyi J O. Effect of highly active antiretroviral therapy on CD4 count and weight in AIDS patients seen at the UITH, Ilorin. Niger J Clin Pract [serial online] 2008 [cited 2020 Aug 15 ];11:312-315
Available from: http://www.njcponline.com/article.asp?issn=1119-3077;year=2008;volume=11;issue=4;spage=312;epage=315;aulast=Olawumi;type=0