Nigerian Journal of Clinical Practice

REVIEW ARTICLE
Year
: 2019  |  Volume : 22  |  Issue : 2  |  Page : 149--153

Association between IL-10 polymorphisms rs1800896 and rs1800871 and risk of acute pancreatitis in Chinese Han population: An update systemic review and meta-analysis


L Dong, Y Zhu 
 Department of Surgery, The Second Affiliated Hospital of Zhejiang University, Hangzhou, P.R. China

Correspondence Address:
Dr. Y Zhu
Department of Surgery, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou
P.R. China

The association between interleukin-10 (IL-10) promoter region (1082 A/G (rs1800896), 819 C/T (rs1800871)) polymorphisms, and acute pancreatitis (AP) is inconclusive in Chinese Han population. In this study, six eligible studies extracted from the databases of PubMed, Web of Science, and Cochrane Library were evaluated. The results revealed a significant association between 1082 A/G (rs1800896) polymorphism and AP risk in all these five models (AG/AA: OR = 1.19, 95% Cl = 1.02–1.40, P = 0.03; GG/AA: OR = 1.80, 95% Cl = 1.38–2.23, P = 0.01; AG+GG/AA: OR = 1.29, 95% Cl = 1.11–1.50, P = 0.01; GG/AG+AA: OR = 1.62, 95% Cl = 1.27–2.08, P = 0.01; G/A: OR = 1.29, 95% Cl = 1.15–1.45, P = 0.01). In contrast, no statistically significant association was found in all these five models for 819 C/T (rs1800871) polymorphism. In summary, IL-10 polymorphism 1082 A/G (rs1800896) could increase the risk of AP in Chinese Han population.


How to cite this article:
Dong L, Zhu Y. Association between IL-10 polymorphisms rs1800896 and rs1800871 and risk of acute pancreatitis in Chinese Han population: An update systemic review and meta-analysis.Niger J Clin Pract 2019;22:149-153


How to cite this URL:
Dong L, Zhu Y. Association between IL-10 polymorphisms rs1800896 and rs1800871 and risk of acute pancreatitis in Chinese Han population: An update systemic review and meta-analysis. Niger J Clin Pract [serial online] 2019 [cited 2019 Feb 17 ];22:149-153
Available from: http://www.njcponline.com/article.asp?issn=1119-3077;year=2019;volume=22;issue=2;spage=149;epage=153;aulast=Dong;type=0