Nigerian Journal of Clinical Practice

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 22  |  Issue : 6  |  Page : 750--753

Up-regulation of hypoxia inducible Factor-1α in patients with diabetic nephropathy


J Wang, S Ye 
 Department of Endocrinology, Anhui Provincial Hospital, Hefei, China

Correspondence Address:
Dr. S Ye
Department of Endocrinology, Anhui Provincial Hospital, Hefei 230001
China

Objective: To study the role of hypoxia inducible factor-1α (HIF-1α) in patients with diabetic nephropathy (DN). Methods: In total, 133 participants were selected to conduct the investigation, parameters such as fasting blood sugar (FBS), blood urea nitrogen (BUN), and urine albumin-creatinine ratio (UACR) were tested and recorded. The biopsy assessment was conducted when renal function or urinary abnormalities. Western blotting was used to test the expression of serum HIF-1α in all patients and control group. Results: The values of FBS, BUN, and UACR were higher in DN and diabetes groups than in the healthy control. The values of FBG, BUN, and UACR were higher in DN patients than in the diabetes patients with no nephropathy. eGFR in DN patients was lower than the other two groups. The expression of HIF-1α was higher than both diabetes patients with no nephropathy and healthy control, P < 0.05. Patients with lots of albuminuria showed the highest expression of HIF-1α than the other groups. HIF-1α in normoalbuminuria and microalbuminuria groups showed no significant difference. Conclusions: HIF-1α was up-regulated in DN patients, which might give clinical basis to the role of HIF-1α in the development of DN.


How to cite this article:
Wang J, Ye S. Up-regulation of hypoxia inducible Factor-1α in patients with diabetic nephropathy.Niger J Clin Pract 2019;22:750-753


How to cite this URL:
Wang J, Ye S. Up-regulation of hypoxia inducible Factor-1α in patients with diabetic nephropathy. Niger J Clin Pract [serial online] 2019 [cited 2019 Sep 17 ];22:750-753
Available from: http://www.njcponline.com/article.asp?issn=1119-3077;year=2019;volume=22;issue=6;spage=750;epage=753;aulast=Wang;type=0