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  Citation statistics : Table of Contents
   2006| December  | Volume 9 | Issue 2  
    Online since January 11, 2011

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Pattern of severe electrical injuries in a Nigerian regional burn centre
KO Opara, TO Chukwuanukwu, IS Ogbonnaya, CU Nwadinigwe
December 2006, 9(2):124-127
BACKGROUND: Electrical injuries, though uncommon usually have devastating consequences. They are largely preventable. The objectives of the study were to highlight the pattern of severe electrical injuries seen in our environment, the management problems faced here compared with other studies and proffer suggestions for improvement and prevention. METHODS: A 10-year retrospective study of case files of patients seen with electrical injuries in our centre was carried out from January 1995 to December 2004. Case notes were retrieved and data collated from them were analysed by descriptive statistics. RESULTS: Twenty four (24) case files met the inclusion criteria and were analysed. Electrical burns constituted 2.8% of total burn admissions. Patients' ages ranged from 15 months to 42 years. Male: Female ratio was 4.8:1. Seven (29%) had high voltage injuries, mostly work-related. Sixteen (67%) had low voltage injuries while one (4%) had a lightening injury. Fourteen (58%) presented or were referred more than 24 hours post injury. Fifteen (63%) had a form of surgical treatment with wound debridement (33%) skin grafting (38%) and amputations (29%) being the commonest ones. The mortality was 12.5% with septicaemia as the leading cause of death. CONCLUSION: Late presentation of patients to specialised centres, inadequate management at the primary centres of treatment, poverty and inadequate facilities even at the specialised centres were the main problems encountered. We recommend re-education of the populace including medical practitioners, enforcement of safety rules in the home and workplaces and upgrading of our health facilities to decrease the menace of severe electrical injuries.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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Aspects of the epidemiology of intestinal parasitoses (IP) in children : knowledge, practices and perceptions of mothers
AI Omoigberale, LU Airauhi
December 2006, 9(2):109-113
BACKGROUND: Intestinal parasitoses (IP) have been demonstrated to pose a major public health problem in the tropics. It is hypothesized that children are continually exposed to re-infection despite interventions. We conducted this hospital-based study to investigate knowledge, practices and perceptions among mothers of children seen at the hospital. METHOD: The study focused on knowledge, practices and perceptions of mothers concerning intestinal parasitoses in children. Questionnaires, which were interviewer administered, were used to generate qualitative data. Stool samples were collected from the study participants into labelled bottles for examination. RESULTS: Majority of mothers belonging to the lower classes did not have access to good drinking water as demonstrated by 39%, 32% in classes III and II respectively while no mother in class V got water from reliable sources: The low level of knowledge about IP was demonstrated by the claim that it was inevitable with the following 68.9% , 56.5%, 44.0% of mothers in social classes V, IV and III respectively. Infection rates increased with lowering social status. More males than females were infected but the difference was not significant (P> 0.05). Peak infection was among children aged between 3 + and 4 years. CONCLUSION: The low level of knowledge, practices and perceptions of mothers concerning IP is a major cause for worry. Urgent consideration should therefore be given in order to periodically treat infected children, enlighted mothers about mode of transmission of IP and also to improve sanitation in deprived areas so as to reduce the rate of transmission.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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The pattern of paediatric HIV/AIDS as seen at the National Hospital Abuja Nigeria
O Oniyangi, B Awani, KC Iregbu
December 2006, 9(2):153-158
BACKGROUND: Paediatric HIV/AIDS has become a significant cause of mortality and morbidity in our environment. OBJECTIVES: The objective of this paper is to determine the mode of transmission, clinical presentations and outcome of hospital admissions in children with Paediatric HIV/AIDS at the National Hospital Abuja Nigeria. METHODS: A retrospective study of children with Paediatric HIV/AIDS admitted into the hospital from January December 2000 was done. Screening for HIV infection was based on clinical criteria as recommended by WHO except in 3 children with previously diagnosed HIV seropositivity. One positive ELISA and one positive Western Blot assay diagnosed HIV seropositivity. RESULTS: Forty-three HIV positive children aged six weeks to nine years (mean 16.5 months, SD 26.32) were admitted into the Paediatric unit (exclusive of the newborn unit) of the hospital, accounting for 5.7% of all admissions into the unit. There were 35 infants (81.4%). There were 18 males and 25 females (male: female ratio 1:0.72). The presumed modes of transmission were mother to child transmission 40(93.02%), blood transfusion 2 (4.6%) and an unidentified route 1 (2.3%). All parents were in the reproductive age group and there were 6 discordant couples identified (mother HIV positive, father HIV negative). Common presenting symptoms were fever 16 (37.2.8%), diarrhoea 13 (30.2%), difficult/fast breathing 12 (27.9%) and vomiting 8 (18.6%), while clinical signs were crepitations in the lungs 27 (62.7%), pallor 22 (51.2%), oral thrush 20 (46.5%), hepatomegaly 18 (41.9%), and dehydration 16 (37.2%). Admitting diagnoses were pneumonia 26 (60.5%), septicaemia 4 (9.3%), diarrhoea with dehydration, intestinal obstruction and malnutrition 2 (4.7%) each. There were 14 deaths (mortality rate 32.6%); accounting for 28.57% of total deaths in the paediatric unit during the period. Thirteen (13) (92.8%) deaths occurred in children aged 2 years old and below. The greatest contributors to mortality were pneumonia 10 (71.4%) and septicaemia 2 (14.3%). Poor nutritional status was associated (p<0.05) with increased mortality. CONCLUSION: The findings indicate that paediatric HIVAIDS occurs predominantly by mother to child transmission and constitutes a significant cause of childhood morbidity and mortality at the National Hospital Abuja Nigeria. We recommend intensification of efforts to implement the existing prevention of mother to child transmission programme and further evaluation ofpneumonia in HIV positive children.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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The effects of highly active antiretroviral therapy (HAART) of stavudine, lamivudine and nevirapine on the CD4 lymphocyte count of HIV-infected Africans : the Nigerian experience
O Erhabor, OA Ejele, CA Nwauche
December 2006, 9(2):128-133
OBJECTIVES: The objective of this study was to investigate the short-term effect of highly active antiretroviral therapy on the CD4 lymphocyte count of HIV-infected Nigerians. DESIGN: A case control study of 70 HIV-infected subjects placed on highly active antiretroviral therapy. Thirty HIV-infected yet to start therapy due to unaffordability were observed as controls. Setting: This study was carried out at the Hematology Department of the University of Port Harcourt Teaching Hospital a 500 bed tertiary hospital and one of the designated antiretroviral therapy pilot centers. METHODS: CD4 lymphocyte count was determined at baseline for subjects and controls. Subjects were placed on HAART for 12 weeks while controls that were yet to start therapy were monitored as controls. CD4 lymphocyte count was repeated after 12 weeks and the differences compared statistically. RESULTS: We observed that subjects and control patients did not differ significantly in their CD4 lymphocyte count at baseline (p>0.05), but after 12 weeks HAART in subjects and untreated control there was a mean increase in CD4 count of (39 cells/microL) in subjects, while untreated controls showed a mean decline of (12 cells/microL) p< 0.05. There was a statistically significant variation in the therapy dependent increases in CD4 count of HAART treated subjects based on pre-therapeutic baseline CD4 count (divide2 = 180.39, p<0.05). The HAART dependent increase in CD4 counts was higher in younger subjects 19-28 years (31 cells/microL) compared to older subjects 49-58 years (21 cells/microL) (p = 0.01). Similarly CD4 response was found higher in females compared to males (p = 0.01). CONCLUSION: This study indicates the importance of accessing the CD4 lymphocyte count of HIV infected patients before the initiation of HAART, its use as a prognostic maker in predicting the initial response to HAART and in determining the optimal time to initiate therapy.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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Male breast cancer in north eastern Nigeria
D Dogo, BM Gali, N Ali, HA Nggada
December 2006, 9(2):139-141
BACKGROUND: Carcinoma of the male breast is generally rare and constitutes 1% of all breast cancers. They often present late in developing countries and therefore has poor prognosis. The aim of this paper is to highlight the pattern of presentation and problems associated with management of this disease in Maiduguri, North Eastern Nigeria. PATIENTS AND METHOD: Case records of eleven (11) histologically diagnosed male breast cancers out of a total of two hundred and ninety-five (295) cases of breast cancer managed at the University of Maiduguri Teaching Hospital between 1989-2003 were retrospectively studied and analysed. RESULTS: Male breast cancer constitutes 3.7% of all cases of breast cancers seen in this hospital during the study period under review. The male to female ratio was 1:26. The peak age range at presentation was 40-49 years and all were advanced at presentation. The time interval between onset of symptoms and presentation were all over 12 months. All the patients either had toilet mastectomy or modified radical mastectomy. In addition, two patients had sub capsular orchidectomy while nine had Tamoxifen. Four patients had additional cytotoxic chemotherapy. Two patients died in the course of follow-up while the rest were lost to follow-up shortly after discharge. Only one patient was followed-up for more than two years. CONCLUSION: Male breast cancer though rare, is a serious clinical problem associated with late presentation. It is hoped that increased public awareness will improve the outcome of management.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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Peripheral lymphadenopathy in Nigerian children
N Adesuwa Olu-Eddo, EE Egbagbe
December 2006, 9(2):134-138
AIM: Peripheral lymphadenopathy remains an extremely common clinical problem in Paediatrics. To define the causes of lymph node enlargement in children in this environment. MATERIAL AND METHODS: A 20 year (1984-2003) retrospective study was conducted on all lymph node biopsies received from children (0-14 years) at the Department of Pathology, University of Benin Teaching Hospital, Benin City, Nigeria. Information derived from this study should serve as a diagnostic guide to clinicians. RESULTS: A total of 126 lymph node biopsies were received from children constituting 22.8% of all lymph nodes biopsies received during the period of study. The mean age was 8.3 years (SD +/- 3.1 years). Most (66.7%) cases were males. Regional adenopathy was observed in 90.5% of cases. Overall, the cervical group of lymph nodes was most commonly affected comprising 64 (50.8%) cases. Tuberculosis was the predominant cause of peripheral lymphadenopathy constituting 61 cases (48.4%) and also the commonest cause of cervical lymphadenopathy (62.5%). Non-specific reactive changes, non Hodgkin's lymphoma, Hodgkin's lymphoma and metastatic carcinoma were seen in 32 (25.4%), 22 (17.4%), 7 (5.6%), and 2 (1.6%) cases respectively. Kaposi sarcoma and sarcoidosis constituted one case each. CONCLUSION: In conclusion, the pattern of disease is similar to that of other developing countries. The triad of symptoms including fever, fatigue and weight loss, were recurrent in tuberculous and lymphoma patients. It is thus, imperative to commence antituberculous therapy only after histological diagnosis.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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High birth weight babies : incidence and foetal outcome in a mission hospital in Benin City, Nigeria
AN Onyiriuka
December 2006, 9(2):114-119
OBJECTIVE: To determine the incidence of delivery of high birth weight (HBW) babies in Benin City and document their foetal outcome. METHODS: All babies with HBW (defined as birth weight 4000 g) were recruited into the study. The maternal records were examined for maternal age, parity, height, gestational weight gain and mode of delivery. The sexes, head circumferences and lengths at birth were documented. Foetal outcome such as stillbirth, birth asphyxia, Erb's palsy, fracture of the clavicles and the need for admission into the Special Care Baby Unit in HBW babies (study group) was compared with that of a control group. RESULTS: The incidence of delivery of a HBW infant was 8.1% with a male preponderance. Maternal parity and age influenced the incidence. The highest incidence was among para 4 women and those aged between 35 and 39 years. The lowest incidence was among para zero and teenage women respectively. Women with a history of delivery of a previous baby with birth weight of 4000g, a gestational weight gain of 13-15 kg and a height >1.63 m had an increased tendency towards delivery of a HBW infant. High birth weight babies were at a higher risk of foetal death and delivery by Caesarean Section. CONCLUSION: Incidence of delivery of HBW infant is relatively high in Benin-City. It is associated with increased rate of Caesarean delivery and foetal death.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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Intraoperative diclofenac for post-adenoidectomy analgesia in small children
PU Nze, F Onyekwulu
December 2006, 9(2):102-104
We investigated the analgesic effect of intra-operative intravenous diclofenac in a randomized, double blind placebo-controlled paralled group study after adenoidectomy in 150 children aged 1-7 years. A standard anaesthetic method was used and all children received oral diazepam as premedication. Anaesthesia was induced with thiopentone and maintained with halothane and nitrous oxide in oxygen with controlled ventilation. Children in the diclofenac group received 1 mg/kg i.v. after induction of anaesthesia followed by an infusion of diclofenac 1 mg/kg over 2 hours. Children in the placebo group received 0.9% saline. At the end of procedure the children were transferred to the recovery room for continuous monitoring of vital signs and assessment of pain. Standard deviation, means, ranges and students' t-test statistics were used for data analysis. Worst pain observed in the recovery room was lower in the diclofenac group both at rest and during swallowing. It was therefore concluded that intravenous diclofenac given intra-operatively has analgesic effect in the immediate post-operative period and it is recommended for small children during adenoidectomy.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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The prevalence of radiological markers of renal osteodystrophy in patients with chronic renal failure in Enugu
UC Odenigbo, CK Ijoma, I Ulasi, AC Udeh, CC Ibeh
December 2006, 9(2):147-152
OBJECTIVES: To study the prevalence of renal osteodystrophy in Chronic renal failure patients in Enugu, using radiological methods. SUBJECTS AND METHODS: Ninety adult patients (56 male and 34 female) were recruited from the renal clinics of the University of Nigeria Teaching Hospital, Enugu over a period of twelve consecutive months. A structured questionnaire was administered and a physical examination carried out at the initial interview. This was followed by other investigations including renal ultrasonography, plain radiographs and laboratory investigations including serum electrolytes, urea and creatinine, calcium and phosphate, total alkaline phosphate and creatinine clearance estimation. RESULTS: There was no obvious relationship between bone pain (a symptom of renal osteodystrophy) and the presence ofradiological features of renal osteodystrophy. The findings of the study showed that renal osteodystrophy, demonstrable by radiography is relatively uncommon, existing in only 3 subjects (3.35%). Among the 3 subjects, 2 showed radiological features of osteitis fibrosa cystica (one male and one female), while the other subject (one female) had radiological features of osteoporosis. All these subjects belonged to group 3 and had been on maintainance haemodialysis for more than 6 months. Other forms of renal osteodystrophy were not demonstrated. CONCLUSION: Renal osteodystrophy is probably not as common in Nigerian patients as in Caucasians and there may be reasons for this.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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To serve and not to count the cost : the challenge and the charge
A Adeniyi
December 2006, 9(2):96-101
Full text not available    [CITATIONS]  [PubMed]
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Bacterial pathogens associated with secondary peritonitis in Lagos University Teaching Hospital (LUTH)
CN Akujobi, CG Nwaigwe, TO Egwuatu, FT Ogunsola
December 2006, 9(2):169-173
Secondary peritonitis is a common and serious form of intra-abdominal infection, often associated with high morbidity and mortality. The overall patient outcome has not markedly improved in spite of advances in patient management. There is therefore need to study the pattern of bacterial pathogens associated with secondary peritonitis in Lagos University Teaching Hospital (LUTH) and the antibiotic susceptibility pattern as that would help in formulation of empiric antibiotic policy on peritonitis and improve the outcome/prognosis of the patients. A prospective study of 35 patients with suspected peritonitis at LUTH between February, 2002 and June 2003 was done. Peritoneal fluids of these patients were collected intra-operatively under aseptic conditions. The specimens were subjected to aerobic and anaerobic studies. Twenty-seven isolates were identified aerobically with Escherichia coli being the most predominant organism 11 (31.4%) followed by Staphylococcus aureus 6 (17.1%) then Klebsiella spp 4 (11.4%). Anaerobic culture showed Prevotella species as the most predominant 14 (40%) followed by Bacteroides fragilis group 8 (22.9%). Overall, Prevotella species were the most predominant organisms isolated in LUTH patients with secondary peritonitis.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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Pattern of clinical features of chronic simple rhinosinusitis in Port Harcourt
OB da Lilly-Tariah
December 2006, 9(2):142-146
OBJECTIVE: To evaluate the symptoms, signs and types of chronic simple rhino-sinusitis. PATIENTS AND METHODS: This is prospective work done over a 2-year period. All the patients had symptoms of more than 8 weeks duration. Only patients with symptoms indicative of chronic rhino-sinusitis were included in the study. All the patients had plain x-rays of the paranasal sinuses done and a radiologist reported such. RESULTS: One hundred and fifteen patients were studied. The male to female ratio was 1:1.4 age range 15 years to 70 years. The mean duration of symptoms was 32.03 months. Rhinorrhoea 100%, stuffy nose 97.4%, sneezing 67.6%, anosmia 54.8% and headache 54.8% were the common symptoms while engorged inferior turbinates 79.1%, anterior nasal discharge 63.5% and postnasal discharge 39.1% were the common findings on examination. The clinical diagnosis was chronic infective sinusitis 72.7%, vasomotor rhinitis 17.4% and allergic rhinitis 10.4%. Engorged turbinate was the commonest radiological comment. CONCLUSION: Chronic infective rhino-sinusitis is the commonest type of chronic rhino-sinusitis seen in this study.
[ABSTRACT]   Full text not available    [CITATIONS]  [PubMed]
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Indications for removal of intrauterine contraceptive devices in Jos, north-central Nigeria
JT Mutihir, IA Ujah, PF Uduagbamen, T Iranloye
December 2006, 9(2):105-108
CONTEXT: Intrauterine contraceptive devices (IUDs) are commonly used reversible methods of contraception. The CuT 380A is recommended for use for 10 years but common observation has shown that they are removed much earlier than the recommended duration ofuse. METHODOLOGY: A retrospective study of all clients presenting at the family planning clinic of Jos University Teaching Hospital, between 1st January 1999 and 31st December 2004, for removal of their IUDs. MAJOR OUTCOMES/RESULTS: The mean (+/- SD) age of the clients was 32.9 +/- 6.9 years and mean parity was 4.0 +/- 2.2. All the women were married. The CuT 380A IUD was used in 99.3% of the cases. The mean duration of IUD use was 51.5 +/- 51.0 months or 4.3 years only, and the commonest indication for removal was the desire for another pregnancy, which was recorded in 170 (30.7%) of the clients. This was followed by back pain in 70 (12.6%). Husbands' disapproval of the use of the device was recorded in 0.9% of the clients. CONCLUSION: The duration of IUD use by clients in our centre was very short. The commonest indication for removal of the device was to restore fertility. Shorter lasting IUDs may need to be revisited if these will cost less for clients wishing to use the method only to postpone pregnancies. More effective counselling may be appropriate for alternative contraceptive methods for this category of clients instead of the IUDs currently being used.
[ABSTRACT]   Full text not available     [PubMed]
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Incidence of leaving against medical advice (LAMA) among patients admitted at the accident and emergency unit of the University of Calabar Teaching Hospital, Calabar, Nigeria
AM Udosen, E Glen, S Ogbudu, E Nkposong
December 2006, 9(2):120-123
BACKGROUND: The causes and incidence of the commonly observed phenomenon of leaving against medical advice (LAMA) in our hospitals have not been studied. This retrospective study was aimed at evaluating its incidence and pattern in order to suggest possible solutions. METHODOLOGY: The case files of patients who left against medical advice at the Casualty unit of the University of Calabar Teaching Hospital between July 2002 and December 2003 were retrieved from the Medical Records Department and information regarding age, sex, education/occupation, religion, diagnosis, reason(s) for leaving and duration of stay in casualty were extracted. RESULTS: A total of 3708 patients were seen at the casualty unit within this period. Ninety-seven patients left against medical advice but only ninety case notes were analyzable. Seven folders had incomplete information. Male/Female ratio was 2:1 and the ages ranged between 7 and 70 years (average 31.5 years). The average duration of stay in Hospital was 2.4 days (110 days). Sixty-five patients (72.2%) were those who had various forms of trauma while 8 (8.8%) had general surgical problems. 19% (17) patients had medical emergencies. CONCLUSION: The youths are the most vulnerable group and the principal causes in our environment are ignorance and poverty. Because of poor documentation in our centres, it was not possible to know where these patients go and the results of their treatments. There is therefore a need for further studies.
[ABSTRACT]   Full text not available     [PubMed]
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The contribution of privately owned hospitals in the provision of essential obstetric care in Nigeria
JE Okonkwo, CC Ibeh
December 2006, 9(2):159-163
OBJECTIVE: To highlight the private sector contribution in the provision of essential obstetric care in Abia State, Southeastern Nigeria. METHOD: Following two workshops a structured questionnaire was used to seek information on the type of facility, ownership, type of services, number of staff, instruments and medical consumables, deliveries and data on clients attended to in the previous twelve months. On the basis of the response the facilities were classified into not essential obstetric care, basic essential obstetric care and comprehensive essential obstetric care. RESULTS: Of 638 facilities visited only 378 offered antenatal and postnatal services. The 13 government hospitals and 173 primary health centers conducted 5601 deliveries. The 146 private hospitals/clinics and 46 maternity homes conducted 21,128 deliveries. Only 121 offered essential obstetric services: 42 basic with 2488 deliveries and 79 comprehensive with 14,489 deliveries. Of the basic essential obstetric facilities that were private, 84.6% were concentrated in the 6 urban local government areas (LGA) leaving 15.4% in the 11 rural LGA. Similarly 85.6% of the comprehensive essential obstetric facilities that were private are concentrated in the 6 urban LGA leaving 14.4% scattered in the 11 rural LGA CONCLUSION: The private sector, with its greater essential obstetric facilities, is concentrated mainly in the 6 urban LGA. This resulted in 14,970 deliveries as against 2007 deliveries in the government facilities. Although there is an apparent neglect of the other 11 LGA, the deliveries in the private facilities constituted over 79% within the study period. This greater contribution should be noted and considered when planning maternal and infant mortality and morbidity reforms in Nigeria.
[ABSTRACT]   Full text not available     [PubMed]
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Reproductive outcome following treatment of intrauterine adhesions in Abuja, Nigeria
ER Efetie
December 2006, 9(2):164-168
CONTEXT: Infertility and menstrual abnormalities continue to constitute a significant bulk of gynaecological consultations. Both of these problems are sometimes traced to intrauterine adhesions (IUA) which is preventable in the majority of cases. Endoscopic lysis under direct vision is being introduced into contemporary practice in Nigeria for the treatment of this condition, and is about to commence in this centre. OBJECTIVE: To evaluate the reproductive outcome following treatment of intrauterine adhesions with the mainly traditional division of adhesions, Lippes loop insertion and exogenous hormone supplementation. STUDY DESIGN, SETTING AND SUBJECTS: A retrospective analysis of IUA at the National Hospital Abuja, Nigeria from the period: from 1st September 1999 to 31st August 2004 was carried out in September 2005 for evaluation of their treatment. One patient was lost to follow up and a total of 71 case records were analyzed. MAIN OUTCOME MEASURES: Reproductive outcome among participants with regard to resumption of normal menstruation and becoming pregnant. RESULTS: The incidence of IUA was 1.73% of new patients. Mean age +/- SD was 29.97 +/- 4.82 years. Patients who were Para 0 to 1 constituted 81.9% of the total. Resumption of normal menstruation occurred in 34 (47.9%) patients. At the time of assessment, 17 women (23.9%) were still amenorrhoeic, 15 women (21.1%) were hypomenorrhoeic while 5 women (7.0%) still had oligomenorrhoea. Eight women (11.3%) had achieved a pregnancy within the study period. CONCLUSION: The reproductive outcome following treatment of intrauterine adhesions in this centre is not encouraging and needs improvement. Adoption of more successful treatment modalities like hysteroscopic adhesiolysis is advocated.
[ABSTRACT]   Full text not available     [PubMed]
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Intravascular haemolysis following treatment of malaria with halofantrine : case report
FA Fehintola, CO Falade, A Sowunmi
December 2006, 9(2):174-175
Full text not available     [PubMed]
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The surgeon and the management of ulcerative colitis : experience from the University of Benin Teaching Hospital, Nigeria
CE Ohanaka, TA Njoku
December 2006, 9(2):176-178
Full text not available     [PubMed]
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Paget's disease of the nipple-areola complex as seen in Benin City, Nigeria
CE Ohanaka, AN Ollu-Eddo
December 2006, 9(2):179-182
Out of a total of 240 patients who were managed at the University of Benin Teaching Hospital, Nigeria, for breast cancer over a ten year period (January 1995-December 2004, 8 (3.3%) were found to have Paget's disease of the nipple-areolar complex. They were all females aged between 38-60 (mean 47.62 years). Duration of symptoms before presentation was between 5 months and 7 years (mean 20.75 months). The left breast was more affected than the right. They all presented with itching, excoriation and ulceration of the nipple and diagnosis was by wedge biopsy of the nipple in early cases and by incisional biopsy in late cases. Most presented with advanced disease. Seven patients had mastectomy while one declined surgery. They all had chemotherapy and tamoxifen. Five died within one year of surgery while the remaining three were lost to follow up. Paget's disease, though rare, requires a high index of suspicion for proper diagnosis.
[ABSTRACT]   Full text not available     [PubMed]
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