Medical and Dental Consultants’ Association of Nigeria
Home - About us - Editorial board - Search - Ahead of print - Current issue - Archives - Submit article - Instructions - Subscribe - Advertise - Contacts - Login 
  Users Online: 449   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Year : 2014  |  Volume : 17  |  Issue : 1  |  Page : 56-61

Effect of the number of portal area on modified histological activity index of viral hepatitis and histological findings

1 Department of Pathology, Haseki Training and Research Hospital, Turkey
2 Department of Pharmacology, Dumlupinar University Faculty of Medicine, Turkey
3 Department of Public Health, Firat University Faculty of Medicine, Turkey
4 Department of Radiology, Haseki Training and Research Hospital, Turkey

Correspondence Address:
M Gurbuzel
Department of Pathology, Haseki Training and Research Hospital, Istanbul
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1119-3077.122840

Rights and Permissions

Aim: Viral hepatitis is one of the most important causes of chronic hepatitis. Liver biopsy is used to verify clinical diagnosis and to evaluate necroinflammation and fibrosis. Biopsy is the guide for therapy and can be performed also after treatment to assess the effect of therapy on liver. This paper aimed to explore histopathological characteristics of biopsy samples, which had been referred to our department with the clinical diagnosis of chronic viral hepatitis, in reference to Ishak Modified Hepatic Activity Index (IMHAI), as well as to compare inflammatory scores and stages in the groups created according to the number of portal area (PA). Materials and Methods: The study included 107 patients that underwent liver biopsy in 2011 being diagnosed with chronic viral hepatitis. Age, gender and type of viral hepatitis were retrospectively reviewed and histological findings such as IMHAI inflammatory score and stage, hepatosteatosis and ground glass hepatocytes were re-assessed by two pathologists. Results: Of the present cases, 97 had chronic hepatitis B, 5 had chronic hepatitis C, and 5 had chronic hepatitis BDThe group with PA number of 2-4 consisted of 8 cases and the group with PA number of 11 and over consisted of 37 cases. Conclusion: Statistical analysis performed by comparing IMHAI inflammatory score and stage with PA revealed that score and stage were significantly higher in PA ≥ 11 groups as compared to PA 2-4 group.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded330    
    Comments [Add]    
    Cited by others 1    

Recommend this journal