Effects of sevoflurane and propofol on S100β and neuron-specific enolase protein levels during cardiopulmonary bypass
AF Erdem1, YN Sahin2, N Dogan3, Z Umudum2, F Bayar4, C Bulut5, HA Alici3, B Erkut6, M Cesur7, M Ceviz8
1 Department of Anesthesiology and Reanimation, Medical Faculty, Sakarya University, Sakarya, Turkey
2 Department of Biochemistry, Ataturk University, Sakarya, Turkey
3 Department of Anesthesiology and Reanimation, Ataturk University, Sakarya, Turkey
4 Department of Anesthesiology and Reanimation, Ministry of Health, Sakarya University Education and Research Hospital, Sakarya, Turkey
5 Department of Biochemistry, Ministry of Health, Kırıkkale Haci Hidayet Dogruer State Hospital, Kırıkkale, Turkey
6 Department of Cardiovascular Surgery, Ministry of Health, Erzurum Education and Research Hospital, Erzurum, Turkey
7 Department of Anesthesiology and Reanimation, Medical Faculty, Gaziantep University, Gaziantep, Turkey
8 Department of Cardiovascular Surgery Medical Faculty, Ataturk University, Sakarya, Turkey
Assoc. Prof. Dr. A F Erdem
Department of Anesthesiology and Reanimation, Medical Faculty, Sakarya University, Sakarya
Source of Support: None, Conflict of Interest: None
Aim: Cardiopulmonary bypass (CPB) is associated with the release of S100β and neuron-specific enolase (NSE) indicating cerebral cell injury. The purpose of the present study was to evaluate the effect of propofol and sevoflurane on S100β and NSE levels in patients undergoing coronary artery bypass grafting (CABG).
Materials and Methods: Twenty male patients undergoing CABG were randomly allocated into two groups. One group received sevoflurane (GS) and the other received propofol (GP). Arterial blood samples for analysis of S100β and NSE levels were taken preoperatively (T1), 30 min after initiation of CPB (T2), at the end of CPB (T3), 1 (T4), 6 (T5) and 24 h (T6) postoperatively.
Results: S100β level was significantly higher compared to all analyzed times at T3 in both groups (P < 0.001). S100β level was significantly higher in GP than GS only at T2 (P = 0.002). NSE level was significantly higher at T3, T4 and T5 than T1 in the GP (P = 0.001, 0.002 and 0.023, respectively), while a significant increase was seen at T3 and T4 in GS group (P = 0.001 and 0.047, respectively).
Conclusion: Our findings showed that both S100β and NSE levels similarly increased during CPB and immediately after CPB during sevoflurane and propofol based anesthesia.