|Year : 2016 | Volume
| Issue : 6 | Page : 799-806
Sociodemographic and clinical correlates of sexual dysfunction among psychiatric outpatients receiving common psychotropic medications in a Neuropsychiatric Hospital in Northern Nigeria
VO Olisah1, TL Sheikh2, ER Abah3, AF Mahmud-Ajeigbe3
1 Department of Psychiatry, Ahmadu Bello University Teaching Hospital, Shika Zaria, Kaduna State, Nigeria
2 Department of Clinical Services, Federal Neuropsychiatric Hospital, Kaduna, Kaduna State, Nigeria
3 Department of Ophthalmology, Ahmadu Bello University Teaching Hospital, Shika Zaria, Kaduna State, Nigeria
|Date of Acceptance||09-Feb-2016|
|Date of Web Publication||4-Nov-2016|
Dr. V O Olisah
Department of Psychiatry, Ahmadu Bello University Teaching Hospital, Shika Zaria, Kaduna State
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Background: Sexual dysfunction is common in patients receiving psychotropic medications and may reduce their quality of life and medication adherence with resultant negative impact on treatment outcomes.
Objectives: In this study, we described the various types of sexual dysfunction among psychiatric outpatients receiving psychotropic medications and the sociodemographic and clinical correlates associated with it.
Settings and Design: A descriptive, cross-sectional study conducted in a Neuropsychiatric Hospital in Northern Nigeria.
Methodology: The participants were made up of a consecutive sample of 255 outpatients attending psychiatric clinic from January to March 2014. Data were collected on sociodemographic items, patient's clinical diagnosis, psychotropic medications received, and duration of treatment. Information about sexual functioning was obtained using the International Index of Erectile Function Questionnaire for the male participants and the Female Sexual Function Index for the female participants.
Results: The mean age of the patients studied was 34.7 years (standard deviation [SD] =5.9), with a mean duration of treatment of 3.8 (SD = 6.5) years. Males constituted 47.8% and patients with schizophrenia constituted 43.1%; other diagnoses include bipolar affective disorder, recurrent depressive disorder, and substance use disorder. The prevalence of sexual dysfunction was 64.3%. Age, employment status, and psychotropic medication use were significantly associated with sexual dysfunction; however, only employment status and psychotropic medication use significantly predicted sexual dysfunction.
Conclusions: We concluded that sexual dysfunction is highly prevalent among patients receiving psychotropic medication; as such inquiries about sexual function should be routinely carried out by clinicians as this may negatively impact on adherence and quality of life.
Keywords: Psychiatric outpatients, psychotropic medications, sexual dysfunction
|How to cite this article:|
Olisah V O, Sheikh T L, Abah E R, Mahmud-Ajeigbe A F. Sociodemographic and clinical correlates of sexual dysfunction among psychiatric outpatients receiving common psychotropic medications in a Neuropsychiatric Hospital in Northern Nigeria. Niger J Clin Pract 2016;19:799-806
|How to cite this URL:|
Olisah V O, Sheikh T L, Abah E R, Mahmud-Ajeigbe A F. Sociodemographic and clinical correlates of sexual dysfunction among psychiatric outpatients receiving common psychotropic medications in a Neuropsychiatric Hospital in Northern Nigeria. Niger J Clin Pract [serial online] 2016 [cited 2020 Oct 26];19:799-806. Available from: https://www.njcponline.com/text.asp?2016/19/6/799/180063
| Introduction|| |
Psychotropic medications are beneficial for the treatment of psychiatric disorders, but almost all have the potential to induce diverse sexual adverse effects.,,, This is further complicated by the effects of major psychiatric disorders on sexual functioning, among which are reduced libido and decreased sexual performance and satisfaction., Sexual dysfunction is a common and distressing symptom in schizophrenia, with rates of up to 86–96% reported in more recent studies. The high rates could be caused by antipsychotic treatment and illness variables such as negative symptoms, direct effects of psychosis, and abnormalities in the limbic system.,,
Masters and Johnson first described a four-stage model of physiological responses to sexual stimulation to include excitement phase, plateau phase, orgasmic phase, and resolution. Their work was criticized on the basis that it only evaluated sexual response from physiological perspective while psychological, emotional, and neuro-cognitive factors need to be taken into consideration. Other researchers described three phases: Desire (libido), excitement (arousal), and orgasm which are interconnected yet have different neurophysiological mechanisms., Neurobiology of these three phases of sexual function shows that libido is primarily regulated by dopamine, arousal by acetylcholine and nitric oxide, and orgasm by serotonin and norepinephrine. Accordingly, antipsychotic drugs that are dopamine antagonists might be expected to decrease libido while the many antidepressants that are serotonin agonists would be likely to interfere with orgasm.
The psychotropic drugs most commonly associated with sexual dysfunction are antidepressants and antipsychotics. Sexual dysfunction has been cited as one of the most common reasons for patients dropping out of treatment with antidepressants. There is very limited published information regarding effects of anticonvulsants, mood stabilizers, and anxiolytic drugs on sexual function. Direct inquiry reveals that delayed orgasm/ejaculation occurs in >50% and anorgasmia in at least one-third of patients given selective serotonin reuptake inhibitors. In addition, sexual dysfunction is greatly underreported by patients., Some studies have examined sexual dysfunction in patients taking tricyclic antidepressants or monoamine oxidase inhibitors and found delayed orgasm in 21% of men and 27% of women taking imipramine, in 30% of men and 36% of women taking phenelzine, and in no men and 11% of women taking placebo. The resolution phase is the passive phase that follows orgasm. Very few studies have specifically looked at the effects of psychotropic medications on this phase of sexual response. Drugs such as benzodiazepines and antidepressants that cause delayed orgasm or anorgasmia do inhibit or prolong the resolution phase of the sexual response cycle.
Decreased libido is very common with the older conventional antipsychotic drugs since they are potent dopamine blockers, with 30–60% of patients experiencing disturbances of sexual function. A study in Southwestern Nigeria involving 275 consecutive outpatients with psychotic disorders on conventional antipsychotics showed that 40.4% of respondents had one or more forms of sexual dysfunction. Sexual desire dysfunction was present in 17.1%, erectile dysfunction in 34.5%, orgasmic dysfunction in 18.5%, intercourse dissatisfaction in 26.2%, and overall dissatisfaction in 23.3% of respondents. Other studies had similar findings and were more likely to be disturbing to men than women.,,, Among the newer atypical antipsychotic drugs, risperidone is most likely to cause elevations in prolactin levels and hyperprolactinemic symptoms such as menstrual disturbances, galactorrhea, erectile dysfunction, and decreased libido., Benzodiazepines, particularly in higher doses, have been most strongly associated with decreased libido and ejaculatory difficulty. Sexual dysfunction has consistently been found to be more common in patients taking carbamazepine and phenytoin than in those taking nonenzyme-inducing anticonvulsants such as lamotrigine and valproate.,,
Despite this high rate, complaints about sexual dysfunction are largely unexplored or ignored by clinicians resulting in poor medication adherence and quality of life. Furthermore, some patients may be shy or have cultural restrictions in discussing their sexual experiences. Most of the studies investigating sexual dysfunction in patients receiving psychotropic medications in Nigeria examined erectile dysfunction in male patients attending outpatient clinics or specific diagnostic groups. In this study, we described the various types of sexual dysfunction among male and female psychiatric outpatients receiving psychotropic medications and sociodemographic and clinical correlates associated with them.
| Methodology|| |
This is a descriptive, cross-sectional study design. Participants were made up of a consecutive sample of 255 male and female outpatients attending clinic in a Northern Nigerian Neuropsychiatric Hospital, which is the only federal government owned public psychiatric hospital in the town. Ethical clearance for the study was obtained from the Research Ethics Committee of the hospital.
Participants included consenting clinic attendees between the ages of 18 and 69 years who were married and/or who had a regular sexual partner and who had fulfilled the International Classification of Diseases-Tenth Edition criteria for a neuropsychiatric disorder at 1 time or the other based on information from patients' case notes and who were currently on psychotropic medications for at least 3 months. The study excluded patients who were too ill to respond to the interview and those with clinical history or record of conditions and medications that may contribute to sexual dysfunction such as diabetes, hypertension, cerebrovascular disorder, and endocrine disorder/medications (all patients undergo routine laboratory screening including fasting/random blood sugar and full physical examination at presentation and regular intervals for any concomitant physical illness at the study center; body weight and blood pressure checks are also carried out at every visit).
The interviews were conducted by a consultant psychiatrist and two trained research assistants (a male and a female psychologist attending to the male and female respondents, respectively) in the outpatient clinic consultation rooms after routine consultation, to ensure confidentiality. Assistance in completing the questionnaires was provided for the respondents where necessary.
Data were collected using a research protocol containing sociodemographic items, patient's clinical diagnosis, psychotropic medications being received, and duration of treatment.
Information about sexual functioning was obtained using the International Index of Erectile Function (IIEF) Questionnaire for the male participants and the Female Sexual Function Index (FSFI) for the female participants.
The International Index of Erectile Function questionnaire
This is a self-administered questionnaire that evaluates male sexual functions. The IIEF was developed by an international panel of experts through an extensive review of the literature and existing questionnaires in addition to a detailed interview of men with sexual dysfunction and their partners. The IIEF instrument consists of 15 questions (Q), rated on a scale of 1–5, with 0 indicating no sexual activity or no attempt. It has five domains: Erectile dysfunction (Q1–5, 15), orgasmic function (Q9, 10), sexual desire (Q11, 12), intercourse satisfaction (Q6–8), and overall satisfaction (Q13, 14), each addressing a unique dimension of sexual function. Total IIEF questionnaire score ranged from 0 to 75, with higher scores indicating better sexual functioning. The instrument has a scoring algorithm showing the five domains of male sexual dysfunction with their cutoff scores. Responses to each question are based on sexual problems experienced over the past 4 weeks. The IIEF has been used by previous authors in Nigeria  and in their study, a reliability coefficient (Cronbach's alpha) of 0.921 was obtained.
The Female Sexual Function Index
This questionnaire was developed as a brief, self-report measure of female sexual function. Initial face validity testing of questionnaire items, identified by an expert panel, was followed by a study aimed at further refining the questionnaire. It was administered to 131 normal controls and 128 age-matched subjects with female sexual arousal disorder (FSAD) at five research centers. Based on clinical interpretations of principal components analysis, a 6-domain structure was identified, which included desire, subjective arousal, lubrication, orgasm, satisfaction, and pain. Overall test-retest reliability coefficients were high for each of the individual domains (r = 0.79–0.86), and a high degree of internal consistency was observed (Cronbach's alpha values of 0.82 and higher). Good construct validity was demonstrated by highly significant mean difference scores between the FSAD and control groups for each of the domains (P < 0.001). The FSFI is a 19-item questionnaire that has six domains: Sexual desire (Q1, 2), sexual arousal (Q3–6), lubrication (Q7–10), orgasm (Q11–13), sexual satisfaction (Q14–16), and sexual pain (Q17–19). The instrument has an algorithm that aids clinical interpretation of results and has been validated in Nigeria.
Statistical Package for Social Sciences version 16.0 (SPSS Inc. Chicago, 2007) was used for data analysis. Most of the variables were grouped for ease of statistical analysis. Results were calculated as frequency (%) and mean. Variables that were found to be significantly associated with any form of sexual dysfunction (independent variables) were then included in a logistic regression model with the presence or absence of sexual dysfunction as the outcome (dependent variable). The level of significance was set at 0.05.
| Results|| |
Two hundred and fifty-five male and female outpatients who met the inclusion criteria were recruited for the study. The mean age was 34.7 (standard deviation [SD] =5.9) years, and they were mainly between 20 and 29 years old (34.1%). The respondents were predominantly unemployed (61.6%) and 52.2% were female [Table 1].
Clinical and medication related variables
The majority of the participants had a diagnosis of schizophrenia (43.1%) and the mean duration of treatment with psychotropic medications was 3.8 (SD = 6.5) years, and median duration was 5.2 years. The mean antipsychotic dose was 408 mg chlorpromazine or equivalent per day, mean tricyclic antidepresant dose was 63 mg amitriptylline or equivalent per day, mean SSRI dose was 20 mg fluoxetine or equivalent per day, mean dose of anticonvulsant/mood stabilizer was 752 mg Carbamazepine, 605 mg sodium valproate per day and mean dose of benzhexol was 6.4 mg per day. About 77% of the participants were using two or more psychotropic medications as at the time of the study [Table 2].
|Table 2: Clinical and medication related characteristics of participants|
Click here to view
One or more forms of sexual dysfunction existed among 164 (64.3%) of the respondents. Of these, female sexual dysfunction constituted 58.8% while male sexual dysfunction constituted 40.2% [Table 3].
Correlates of sexual dysfunction
Sociodemographic-, medication-, and illness-related variables associated with one or more forms of sexual dysfunction in males and females are shown in [Table 4] and [Table 5], respectively.
|Table 4: Association between specific sexual dysfunctions and sociodemographic, clinical and medication-related variables in male participants|
Click here to view
|Table 5: Association between specific sexual dysfunctions and socio-demographic, clinical and medication-related variables in female participants|
Click here to view
Independent correlates of sexual dysfunction
Regression analysis showed that unemployment in males (P = 0.04) and psychotropic medication use in males and females (P = 0.026 and 0.011, respectively) were the only significant predictors of sexual dysfunction.
| Discussion|| |
The current study examined the prevalence and correlates of sexual dysfunction among male and female psychiatric outpatients receiving psychotropic medications in a Neuropsychiatric Hospital in Northern Nigerian.
The study population consisted of approximately equal proportion of male and female participants, the majority of whom were unemployed (61.6%) with mean age of 34.7 years reflective of the adult clinic population where the study was conducted. The high unemployment ratio may be indicative of impaired occupational functioning resulting from their clinical diagnoses as majority had schizophrenia (43.1%), a condition known to impair occupational functioning.
About 77% of the participants were using two or more psychotropic medications as at the time of the study similar to an observation made in a study examining the prescribing habits for psychiatric inpatient admissions. The highest combination was those on typical antipsychotics and benzhexol constituting 27.8% followed by those on typical antipsychotics, benzhexol, and antidepressant combination (13.3%). These medications are known to individually cause sexual adverse effects via their mechanisms of action;,,, therefore, combinations such as these will more likely precipitate sexual adverse effects in patients.
Overall, about 64.3% of the respondents had at least one form of sexual dysfunction. This rate is similar to that reported in previous studies., Considering the finding that the mean age (34.7 years) of the respondents fell within the reproductive age group, problems with their sexual functioning may be a significant source of concern for them with far reaching consequences if left untreated.
Erectile dysfunction was found to be the most common sexual dysfunction in men (40.2%) receiving psychotropic medication. This was followed by sexual desire dysfunction (25.4%) and then orgasmic dysfunction (20.5%). This finding is similar to the observation made in some other studies.,, A difference was observed for the female where orgasmic dysfunction was found to be the most common type of sexual dysfunction (46.6%), followed by arousal and lubrication disorders (36.1% and 29.3%, respectively). This is similar to findings in some other studies looking at sexual dysfunction in women taking psychotropic medications. This observed sex difference is in keeping with the natural differences observed by previous researchers in male and female disorders of sexual response where erectile dysfunction was found to be the most common sexual dysfunction in men and orgasmic dysfunction in the women in general population studies. This study also found that men were more dissatisfied with their sexual functioning (12.3%) compared to women (7.5%) and similar to some other studies which found that sexual dysfunction is more disturbing in men than in women taking psychotropic medications.,, It was not surprising that sexual arousal and desire dysfunction was found to be common among participants in this study considering the fact that majority of them were on multiple psychotropic medications, especially conventional antipsychotic (antidopaminergic), benzhexol (anticholinergic), and antidepressant (serotonergic/noradrenergic) combinations. Studies have found that libido is primarily regulated by dopamine, arousal by acetylcholine and nitric oxide, and orgasm by serotonin and noradrenaline. Therefore, the mechanism of action of these psychotropic medications may be implicated as a cause of sexual dysfunction. Inability to achieve a good penile erection for optimal sexual satisfaction in men may be associated with feelings of inadequacy. In many societies, individuals with erectile dysfunction are often stigmatized and may be deserted by their spouse. Once patients recognize that their psychotropic medications produce one form of sexual dysfunction or the other, it often results in poor treatment adherence.
This study found that erectile and orgasmic dysfunction was significantly associated with age among the male participants while lubrication disorder and orgasmic dysfunction were significantly associated with age in the females. These associations may not be different from the natural changes that occur in male and female sexuality with aging as previous researchers have reported that erectile dysfunction in males and orgasmic dysfunction in females increases with age. However, psychotropic medication use is likely to further increase the risk of developing these sexual adverse effects through their mechanisms of action.,,
This study reports that employment status was significantly associated with sexual desire dysfunction, erectile dysfunction, orgasmic dysfunction, and overall sexual dissatisfaction in the male participants similar to the finding in some other studies  while in the female participants, only orgasmic dysfunction was found to be significantly associated with employment status. Overall, employment status was found to be predictive of sexual dysfunction in male patients receiving psychotropic medication. Unemployment seems to have more impact on the male sexuality and may result in role reversal within a relationship, bringing about feelings of inadequacy in the male partner which may negatively impact on self-worth and sexual performance or satisfaction. Several studies have shown that unemployment was associated with low sexual desire and erectile dysfunction in the general population., It is very likely that financial stress might have negative impact on sexual functioning in population of unemployed mentally ill subjects.
This research showed no association between the clinical diagnoses of participants and sexual dysfunction, probably because the sample was made up of patients whom were mostly stable on psychotropic medications. However, some previous studies have found attributable effects of major psychiatric disorders on sexual functioning, among which are reduced libido and decreased sexual performance and satisfaction.,
Psychotropic medication use was found to predict sexual dysfunction in male and female participants. This may occur as a result of the effects of psychotropic drugs on catecholamines and their effects on sexual function. This may be even more relevant since as many as 76.9% of study participants were on multiple psychotropic medications. The study found that typical antipsychotic use was associated with erectile dysfunction in males and orgasmic dysfunction in males and females while antidepressant use was associated with orgasmic dysfunction in males and females similar to findings in some other studies.,, This is believed to be due to the effects of these medications on the various catecholamines that play important roles in sexual functioning.
Sexual dysfunction has been cited as one of the most common reasons for patients dropping out of treatment with psychotropic medications. In addition, it is greatly underreported by patients and unexplored or ignored by clinicians resulting in poor medication adherence and quality of life. The diagnosis of psychotropic drug-induced sexual dysfunction is easy if the psychiatrist is sensitive to the existence of these adverse effects. Physicians should take sexual histories as a routine practice when prescribing psychotropic drugs. Diagnosis is usually established if the sexual dysfunction develops when the patient is receiving a psychotropic drug and then disappears when the offending drug is discontinued.
This study described the various types of sexual dysfunction among male and female psychiatric outpatients receiving psychotropic medications in the Northern Nigerian Neuropsychiatric Hospital and highlighted the magnitude of the problem. It is hoped that this will create awareness and encourage the need for routine screening for sexual dysfunction in all patients receiving psychotropic medications so as to institute appropriate care.
This study has a number of limitations. First, it was cross-sectional in design, so the direction of causality between sexual dysfunction and the sociodemographic and clinical variables could not be inferred from the findings. Second, there is a limitation regarding the generalizability of the result to other patients on psychotropic medications in Nigeria as the study was conducted in just one center. Third, the absence of a control group is an important limitation to the generalizability of our results, especially as we know from literature that psychiatric conditions may also give rise to various types of sexual dysfunction.
| Conclusion|| |
Sexual dysfunction is common among psychiatric outpatients on psychotropic medications and is associated with demographic-, illness-, and medication-related variables; as such inquiries about sexual dysfunction should be routinely carried out by clinicians to improve case identification and encourage effective treatment.
I wish to acknowledge the material support from the management of Federal Neuropsychiatric Hospital, Kaduna, by providing stationeries used in the study.
Financial support and sponsorship
Federal Neuropsychiatric Hospital, Kaduna, Nigeria.
Conflicts of interest
There are no conflicts of interest.
| References|| |
Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: A prospective multicenter study of 1022 outpatients. Spanish working group for the study of psychotropic-related sexual dysfunction. J Clin Psychiatry 2001;62 Suppl 3:10-21.
Stimmel GL, Gutierrez MA. Sexual dysfunction and psychotropic medications. CNS Spectr 2006;11 8 Suppl 9:24-30.
Aizenberg D, Modai I, Landa A, Gil-Ad I, Weizman A. Comparison of sexual dysfunction in male schizophrenic patients maintained on treatment with classical antipsychotics versus clozapine. J Clin Psychiatry 2001;62:541-4.
Cutler AJ. Sexual dysfunction and antipsychotic treatment. Psychoneuroendocrinology 2003;28 Suppl 1:69-82.
Macdonald S, Halliday J, MacEWAN T, Sharkey V, Farrington S, Wall S, et al.
Nithsdale schizophrenia surveys 24: Sexual dysfunction. Case-control study. Br J Psychiatry 2003;182:50-6.
Baldwin D, Mayers A. Sexual side-effects of antidepressant and antipsychotic drugs. Adv Psychiatr Treat 2003;9:202-10.
Bitter I, Basson BR, Dossenbach MR. Antipsychotic treatment and sexual functioning in first-time neuroleptic-treated schizophrenic patients. Int Clin Psychopharmacol 2005;20:19-21.
Malik P. Sexual dysfunction in schizophrenia. Curr Opin Psychiatry 2007;20:138-42.
Masters WH, Johnson VE. Human Sexual Response. 1st
ed. Little, Brown & Co., Boston: Bontam; 1966.
Schiavi RC, Segraves RT. The biology of sexual function. Psychiatr Clin North Am 1995;18:7-23.
Stahl SM. The psychopharmacology of sex, Part 1: Neurotransmitters and the 3 phases of the human sexual response. J Clin Psychiatry 2001;62:80-1.
Stahl SM. The psychopharmacology of sex, part 2: Effects of drugs and disease on the 3 phases of human sexual response. J Clin Psychiatry 2001;62:147-8.
Montejo-González AL, Llorca G, Izquierdo JA, Ledesma A, Bousoño M, Calcedo A, et al.
SSRI-induced sexual dysfunction: Fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 1997;23:176-94.
Michels KB. Problems assessing nonserious adverse drug reactions: Antidepressant drug therapy and sexual dysfunction. Pharmacotherapy 1999;19:424-9.
Harrison WM, Rabkin JG, Ehrhardt AA, Stewart JW, McGrath PJ, Ross D, et al.
Effects of antidepressant medication on sexual function: A controlled study. J Clin Psychopharmacol 1986;6:144-9.
Boyarsky BK, Hirschfeld RM. The management of medication-induced sexual dysfunction. Essent Psychopharmacol 2000;3:151-70.
Oyekanmi AK, Adelufosi AO, Abayomi O, Adebowale TO. Demographic and clinical correlates of sexual dysfunction among Nigerian male outpatients on conventional antipsychotic medications. BMC Res Notes 2012;5:267.
Smith SM, O'Keane V, Murray R. Sexual dysfunction in patients taking conventional antipsychotic medication. Br J Psychiatry 2002;181:49-55.
Fakhoury WK, Wright D, Wallace M. Prevalence and extent of distress of adverse effects of antipsychotics among callers to a United Kingdom National Mental Health Helpline. Int Clin Psychopharmacol 2001;16:153-62.
Bobes J, Garc A-Portilla MP, Rejas J, Hern Ndez G, Garcia-Garcia M, Rico-Villademoros F, et al.
Frequency of sexual dysfunction and other reproductive side-effects in patients with schizophrenia treated with risperidone, olanzapine, quetiapine, or haloperidol: The results of the EIRE study. J Sex Marital Ther 2003;29:125-47.
Kinon BJ, Gilmore JA, Liu H, Halbreich UM. Hyperprolactinemia in response to antipsychotic drugs: Characterization across comparative clinical trials. Psychoneuroendocrinology 2003;28 Suppl 2:69-82.
Knegtering R. Sexual dysfunctions in patients on antipsychotics. In: Antipsychotic Medications and Sexuality. Program and abstracts from the 153rd
Annual American Psychiatric Association Meeting, Chicago, Illinois; May 13-18, 2000. [Abstract S35].
Seagraves RT. The effects of minor tranquilizers, mood stabilizers, and antipsychotics on sexual function. Prim Psychiatry 1997;4:46-8.
Herzog AG, Drislane FW, Schomer DL, Pennell PB, Bromfield EB, Kelly KM, et al.
Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: Interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs. Epilepsia 2004;45:764-8.
Morrell MJ, Flynn KL, Doñe S, Flaster E, Kalayjian L, Pack AM. Sexual dysfunction, sex steroid hormone abnormalities, and depression in women with epilepsy treated with antiepileptic drugs. Epilepsy Behav 2005;6:360-5.
Gopalakrishnan R, Jacob KS, Kuruvilla A, Vasantharaj B, John JK. Sildenafil in the treatment of antipsychotic-induced erectile dysfunction: A randomized, double-blind, placebo-controlled, flexible-dose, two-way crossover trial. Am J Psychiatry 2006;163:494-9.
Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urol 1997;49(6):822-30.
Mosaku KS, Ukpong DI. Erectile dysfunction in a sample of patients attending a psychiatric outpatient department. Int J Impot Res 2009;21:235-9.
Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al.
The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000;26:191-208.
Nwagha UI, Oguanuo TC, Ekwuazi K, Olubobokun TO, Nwagha TU, Onyebuchi AK, et al.
Prevalence of sexual dysfunction among females in a university community in Enugu, Nigeria. Niger J Clin Pract 2014;17:791-6.
Inagaki N, Inada T. The 5th
dose conversion in new antipsychotic drugs (part 5). Jap J Clin Psychopharmacol 2008;11:887-90.
Regier L, Jenson B. Antidepressant Comparism Chart; 2003. Available from: http://www.rxfiles.ca
. [Last retrieved on 2012 Sep 09].
Adamson TA. Prescribing habits for psychiatric in-patient admissions in a Nigerian psychiatric hospital. Afr J Med Med Sci 1995;24:261-7.
Rosen RC. Prevalence and risk factors of sexual dysfunction in men and women. Curr Psychiatry Rep 2000;2:189-95.
DiMeo PJ. Psychosocial and relationship issues in men with erectile dysfunction. Urol Nurs 2006;26:442-6.
Fatusi AO, Ijadunola KT, Ojofeitimi EO, Adeyemi MO, Omideyi AK, Akinyemi A, et al.
Assessment of andropause awareness and erectile dysfunction among married men in Ile-Ife, Nigeria. Aging Male 2003;6:79-85.
May JL, Bobele M. Sexual dysfunction and the unemployed male professional. J Sex Marital Ther 1988;14:253-62.
Abdo CH, Oliveira Júnior WM, Moreira Júnior E, Abdo JA, Fittipaldi JA. The impact of psychosocial factors on the risk of erectile dysfunction and inhibition of sexual desire in a sample of the Brazilian population. Sao Paulo Med J 2005;123:11-4.
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]
|This article has been cited by|
||Evaluation of sexual dysfunction and quality of life in patients with severe mental illness: A cross-sectional study from a tertiary care center in Chhattisgarh
| ||Deepak Ghormode,Pramod Gupta,Devendra Ratnani,Jitender Aneja |
| ||Industrial Psychiatry Journal. 2019; 28(1): 75 |
|[Pubmed] | [DOI]|
||Sexual dysfunction in Chinese rural patients with schizophrenia
| ||Ying-Hua Huang,Cai-Lan Hou,C. H. Ng,Xie Chen,Qian-Wen Wang,Zhuo-Hui Huang,Fu-Jun Jia |
| ||BMC Psychiatry. 2019; 19(1) |
|[Pubmed] | [DOI]|
||Sexual dysfunction among patients with schizophrenia in South West, Nigeria
| ||Oluyomi Esan,Arinola Esan |
| ||Journal of Sex & Marital Therapy. 2018; : 01 |
|[Pubmed] | [DOI]|