Nigerian Journal of Clinical Practice

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 21  |  Issue : 6  |  Page : 735--742

A 3-year study of deferasirox therapy in sickle cell disease patients in Basra, Southern Iraq


AM Mohsin1, MK Hassan2 
1 Center for Hereditary Blood Diseases, Basra Maternity and Children Hospital, Basra, Iraq
2 Center for Hereditary Blood Diseases, Basra Maternity and Children Hospital; Department of Pediatrics, College of Medicine, University of Basra, Basra, Iraq

Correspondence Address:
Dr. M K Hassan
Department of Pediatrics, College of Medicine, University of Basra, Basra
Iraq

Background: Patients with sickle cell disease (SCD) may require repeated transfusions, which inevitably lead to iron overload (IOL). Aims: This study aims to assess the effectiveness and safety of oral deferasirox (DFX) in patients with SCD and transfusional IOL. Patients and Methods: A descriptive study has been performed on patients with SCD who have completed at least 3 years on DFX. Height and weight were checked every 3–6 months. The efficacy was assessed based on serum ferritin (SF) levels. The safety was assessed based on adverse events (AEs), alanine aminotransferase (ALT), and serum creatinine (S. Cr) levels. Results: A total of 102 patients (61 males and 41 females) were recruited. Their mean daily iron intake was 0.13 ± 0.06 mg/kg. SF levels declined significantly from 2434.1 ± 132.9 ng/ml at the start of the study to 1655.8 ± 154.2 ng/ml at the end of the study (P < 0.05), with significant decreases observed after increasing the DFX dose to ≥ 30 mg/kg/day. ALT (12.8 ± 9.9 vs. 12.1 ± 7.1 U/L) and S. Cr (72.4 ± 9.2 vs. 74.1 ± 7.9 mmol/L) levels did not show significant differences from the start to the end of the study (P > 0.05). Thirty-eight patients (37%) developed AEs. The most common were abdominal pain (24.5%), diarrhea (8.0%), and nausea (7.8%). AEs were predominantly transient and mild to moderate in nature. Conclusions: This study has revealed that DFX is a safe, tolerable, and effective drug for reducing IOL in SCD patients, though it is associated with mild and transient adverse events.


How to cite this article:
Mohsin A M, Hassan M K. A 3-year study of deferasirox therapy in sickle cell disease patients in Basra, Southern Iraq.Niger J Clin Pract 2018;21:735-742


How to cite this URL:
Mohsin A M, Hassan M K. A 3-year study of deferasirox therapy in sickle cell disease patients in Basra, Southern Iraq. Niger J Clin Pract [serial online] 2018 [cited 2021 Sep 19 ];21:735-742
Available from: https://www.njcponline.com/article.asp?issn=1119-3077;year=2018;volume=21;issue=6;spage=735;epage=742;aulast=Mohsin;type=0